3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

Base Information

Chemical Name:3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester
CAS No.:326902-42-5
Molecular Formula:C₃₆H₄₃N₃O₁₁
Molecular Weight:693.751
Hs Code.:

3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

Synonyms:3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

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Chemical Property of 3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

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Technology Process of 3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

There total 9 articles about 3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 326902-29-8
(1R,2S,5S,6R)-3-Aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

: 326902-39-0
(1R,2S,5S,6R)-3-[(1R,2S,5S,6R)-3-(2,2-Dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 6-methyl ester

: 326902-42-5
3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

Guidance literature:: With dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jo001201o

Reference yield:

: 220623-25-6
(1R,2S,5S,6R)-3-aza-3-<(tert-butyl)oxycarbonyl>-6-methoxycarbonylbicyclo<3.1.0>hexyl-2-carboxylic acid

: 326902-42-5
3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 82 percent / diisopropylcarbodiimide; DMAP / CH₂Cl₂ / 12 h / 0 - 20 °C

2: 0.37 g / TFA / CH₂Cl₂ / 0.5 h / 20 °C

3: 0.46 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

4: 92 percent / hydrogen / Pd/C / ethyl acetate

5: 77 percent / DCC / CH₂Cl₂ / 4 h

6: 78 percent / hydrogen / Pd/C / ethyl acetate

7: 91 percent / DCC / CH₂Cl₂

With dmap; hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; diisopropyl-carbodiimide; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo001201o

Reference yield:

: 326902-26-5
benzyl (1R,2S,5S,6R)-3-aza-3-(tert-butyloxycarbonyl)-6-(methoxycarbonyl)bicyclo[3.1.0]hexane-2-carboxylate

: 326902-42-5
3-{3-[3-(2,2-dimethyl-propionyl)-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl]-6-methoxycarbonyl-3-aza-bicyclo[3.1.0]hexane-2-carbonyl}-3-aza-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid 2-benzyl ester 6-methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 0.37 g / TFA / CH₂Cl₂ / 0.5 h / 20 °C

2: 0.46 g / Et₃N / CH₂Cl₂ / 1 h / 0 °C

3: 92 percent / hydrogen / Pd/C / ethyl acetate

4: 77 percent / DCC / CH₂Cl₂ / 4 h

5: 78 percent / hydrogen / Pd/C / ethyl acetate

6: 91 percent / DCC / CH₂Cl₂

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jo001201o