3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

Base Information

Chemical Name:3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one
CAS No.:155591-01-8
Molecular Formula:C₁₉H₁₇NO₃S
Molecular Weight:339.415
Hs Code.:

3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benz<e>indol-8-one

Synonyms:3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

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Technology Process of 3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

There total 4 articles about 3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 74-85-1
ethene

: 155591-00-7
1-(p-toluenesulfonyl)indol-4-acetic acid

: 155591-01-8
3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

Guidance literature:: 1-(p-toluenesulfonyl)indol-4-acetic acid; With thionyl chloride; In dichloromethane; for 2h;

ethene; With aluminum (III) chloride; In dichloromethane; at -20 ℃; for 1.25h;

Reference yield:

: 74-85-1
ethene

: 1027843-58-8
[1-(Toluene-4-sulfonyl)-1H-indol-4-yl]-acetyl chloride

: 155591-01-8
3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

Guidance literature:: With aluminium trichloride; In dichloromethane; at -20 ℃; for 1h; Yield given;
DOI:10.1002/jhet.5570310123

Reference yield:

: 92573-18-7
ethyl 1-{[(4-methylphenyl)sulfonyl]-1H-indol-4-yl}acetate

: 155591-01-8
3-(p-toluenesulfonyl)-6,7,8,9-tetrahydro-3H-benzindol-8-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 3 N aq. NaOH / methanol / 2 h / Ambient temperature

2: SOCl₂ / CH₂Cl₂ / 2 h / Ambient temperature

3: AlCl₃ / CH₂Cl₂ / 1 h / -20 °C

With sodium hydroxide; aluminium trichloride; thionyl chloride; In methanol; dichloromethane;
DOI:10.1002/jhet.5570310123