N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide

Base Information

• Chemical Name: N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide
• CAS No.: 1430728-65-6
• Molecular Formula: C₁₈H₁₃BrN₄OS
• Molecular Weight: 413.297
• Mol file: 1430728-65-6.mol

Synonyms:N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide

Chemical Property of N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide

There total 9 articles about N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

formic acid (64-18-6) + N-(3-(2-amino-4-bromophenylamino)-5-(thiazol-2-yl)phenyl)acetamide (1430728-64-5) → N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide (1430728-65-6)

Guidance literature:

at 80 ℃; for 2h;

Reference yield:

3,5-dinitrobromobenzene (18242-39-2) → N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide (1430728-65-6)

Guidance literature:

Multi-step reaction with 8 steps

1: acetic acid; iron / acetic acid / 0.5 h / 90 °C

2: 0.5 h / 0 - 20 °C

3: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

5: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

6: potassium fluoride / N,N-dimethyl-formamide / 7 h / 80 °C

7: ammonium chloride; zinc / water; tetrahydrofuran / 20 °C

8: ethyl acetate / 2 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; palladium 10% on activated carbon; hydrogen; potassium acetate; iron; sodium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

meta-dinitrobenzene (99-65-0) → N-(3-(5-bromo-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide (1430728-65-6)

Guidance literature:

Multi-step reaction with 9 steps

1: sulfuric acid; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / 12.5 h / 0 - 20 °C

2: acetic acid; iron / acetic acid / 0.5 h / 90 °C

3: 0.5 h / 0 - 20 °C

4: potassium acetate; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

5: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate / water; 1,2-dimethoxyethane / 2 h / 90 °C / Inert atmosphere

6: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 12 h / Inert atmosphere

7: potassium fluoride / N,N-dimethyl-formamide / 7 h / 80 °C

8: ammonium chloride; zinc / water; tetrahydrofuran / 20 °C

9: ethyl acetate / 2 h / 80 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium fluoride; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; sulfuric acid; palladium 10% on activated carbon; hydrogen; potassium acetate; iron; sodium carbonate; ammonium chloride; acetic acid; zinc; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide;

upstream raw materials:

3,5-dinitrobromobenzene

meta-dinitrobenzene

1-amino-3-bromo-5-nitrobenzene

N-(3-bromo-5-nitrophenyl)acetamide

Downstream raw materials:

N-(3-(5-(1-methyl-1H-pyrazol-4-yl)-1H-benzo[d]imidazol-1-yl)-5-(thiazol-2-yl)phenyl)acetamide