6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

Base Information

Chemical Name:6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile
CAS No.:328543-72-2
Molecular Formula:C₁₈H₁₂FN₃O
Molecular Weight:305.311
Hs Code.:

Synonyms:6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

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Chemical Property of 6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

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Technology Process of 6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

There total 7 articles about 6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 6-(4-fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbaldehyde oxime

: 328543-72-2
6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

Guidance literature:: With di(1H-imidazol-2-yl)methanethione; In tetrahydrofuran; at 20 ℃; for 4h;
DOI:10.1021/jm030513r

Reference yield:

: 88681-68-9
di(1H-imidazol-2-yl)methanethione

: 6-(4-fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbaldehyde oxime

: 328543-72-2
6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

Guidance literature:: In tetrahydrofuran; methanol; chloroform; ethyl acetate;

Reference yield:

: 766-98-3
1-ethynyl-4-fluorobenzene

: 328543-72-2
6-(4-Fluoro-phenyl)-1-oxo-1,2,3,4-tetrahydro-[1,4]diazepino[6,7,1-hi]indole-7-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: tetrakistriphenylphosphine palladium chloride; CuI; diethylamine / dimethylformamide / 2 h / 20 °C

2.1: PdCl₂ / acetonitrile / 3.5 h / 70 - 80 °C

3.1: POCl₃ / 0 °C

3.2: 94 percent / 20 °C

4.1: NH₂OH*HCl; pyridine / 20 h / 20 °C

5.1: 94 percent / thiocarbonyldiimidazole / tetrahydrofuran / 4 h / 20 °C

With pyridine; copper(l) iodide; tetrakistriphenylphosphine palladium chloride; hydroxylamine hydrochloride; di(1H-imidazol-2-yl)methanethione; diethylamine; palladium dichloride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm030513r