2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Base Information

Chemical Name:2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel
CAS No.:521087-18-3
Molecular Formula:C₅₆H₈₇NO₁₂Si₃
Molecular Weight:1050.56
Hs Code.:

Synonyms:2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Suppliers and Price of 2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

There total 4 articles about 2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 994-30-9
triethylsilyl chloride

: 521087-17-2
2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)docetaxel

: 521087-18-3
2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: With 1H-imidazole; In dichloromethane; acetonitrile; at 60 ℃; for 1.5h;
DOI:10.1002/ejoc.200390092

Reference yield:

: 114915-20-7,114977-28-5,114977-29-6,133577-32-9,133577-33-0
Docetaxel

: 521087-18-3
2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 0.75 h / 0 °C

3: 58 percent / imidazole / acetonitrile; CH₂Cl₂ / 1.5 h / 60 °C

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200390092

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 521087-18-3
2'-O-(tert-butyldimethylsilyl)-3'-(de-tert-butoxycarbonyl)-7,10-bis(triethylsilyl)docetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: 87 percent / imidazole / dimethylformamide / 4 h / 20 °C

2: 83 percent / trifluoroacetic acid / CH₂Cl₂ / 0.75 h / 0 °C

3: 58 percent / imidazole / acetonitrile; CH₂Cl₂ / 1.5 h / 60 °C

With 1H-imidazole; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/ejoc.200390092