4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

Base Information

Chemical Name:4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid
CAS No.:209679-63-0
Molecular Formula:C₃₈H₄₀N₆O₁₁
Molecular Weight:756.769
Hs Code.:

Synonyms:4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

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Chemical Property of 4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

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Technology Process of 4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

There total 3 articles about 4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 209679-62-9
N-{tris[(2-tert-butoxycarbonyl)ethyl]methyl}-N'-[4'-oxa-(2,2':6',2''-terpyridinyl)]-5-nitroisophthalimide

: 209679-63-0
4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

Guidance literature:: With formic acid; at 25 ℃; for 12h;
DOI:10.1021/ja001401h

Reference yield:

: 73585-90-7
5-nitroisophthalic monoacyl chloride

: 209679-63-0
4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 54 percent / Et₃N / tetrahydrofuran / 12 h / -5 °C

2.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 1 h / 25 °C

2.2: 84 percent / dimethylformamide

3.1: 95 percent / HCO₂H / 12 h / 25 °C

With formic acid; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ja001401h

Reference yield:

: 209679-61-8
N-{tris[(2-tert-butoxycarbonyl)ethyl]methyl}-5-nitroisophthalimide monocarboxylic acid

: 209679-63-0
4-(2-carboxy-ethyl)-4-{3-nitro-5-[5-([2,2';6',2'']terpyridin-4'-yloxy)-pentylcarbamoyl]-benzoylamino}-heptanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: dicyclohexylcarbodiimide; 1-hydroxybenzotriazole / dimethylformamide / 1 h / 25 °C

1.2: 84 percent / dimethylformamide

2.1: 95 percent / HCO₂H / 12 h / 25 °C

With formic acid; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/ja001401h