3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Base Information

Chemical Name:3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine
CAS No.:135426-53-8
Molecular Formula:C₂₃H₂₀Br₂FN
Molecular Weight:489.225
Hs Code.:

Synonyms:3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Suppliers and Price of 3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of 3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

There total 9 articles about 3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

CBr₄: CBr₄

: 75-09-2
dichloromethane

: 2-(1,1-Dimethylethyl)-4-(4-fluorophenyl)-6-phenyl-3-pyridine carboxaldehyde

: 135426-53-8
3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Guidance literature:: With sodium hydrogencarbonate; triphenylphosphine; SiO₂; In hexane; acetonitrile;

Reference yield:

: 17094-34-7
ethyl pivaloylacetate

: 135426-53-8
3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 1608-51-1
4-fluorochalcone

: 135426-53-8
3-(2,2-Dibromoethenyl)-2-(1,1-dimethylethyl)-4-(4-fluorophenyl)-6-phenyl pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 4.5 h / Ambient temperature

2: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

3: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

4: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

5: triphenylphosphine / CH₂Cl₂ / 0.42 h / Ambient temperature

With lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; triphenylphosphine; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019