(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

Base Information

Chemical Name:(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide
CAS No.:1448441-08-4
Molecular Formula:C₃₈H₃₇BrN₆O₆
Molecular Weight:753.652
Hs Code.:

Synonyms:(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

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Chemical Property of (R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

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Technology Process of (R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

There total 13 articles about (R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20769-85-1
2-bromoisobutyric acid bromide

: 1448441-18-6
(R)-1-(2-(2-aminobenzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl)pyrrolidine-2-carboxamide

: 1448441-08-4
(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/ja405455g

Reference yield:

: 610-14-0
2-nitrobenzyl chloride

: 1448441-08-4
(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane

2: lithium hydroxide; water / methanol / 4 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C / Molecular sieve

5: palladium(II) hydroxide; methanol / 4 h

6: methylamine / methanol / 1 h / 20 °C

7: triethylamine / dichloromethane / 1 h / 0 °C

With methanol; oxalyl dichloride; water; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; methylamine; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g

Reference yield:

: 134-20-3
2-carbomethoxyaniline

: 1448441-08-4
(R)-1-(2-(2-((2-bromopropan-2-yl)amino)benzamido)benzoyl)-N-(2-((2-(methylcarbamoyl)phenyl)carbamoyl)phenyl) pyrrolidine-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine / dichloromethane

2: lithium hydroxide; water / methanol / 4 h / 20 °C

3: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 0 - 20 °C

4: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 2 h / 20 °C / Molecular sieve

5: palladium(II) hydroxide; methanol / 4 h

6: methylamine / methanol / 1 h / 20 °C

7: triethylamine / dichloromethane / 1 h / 0 °C

With methanol; oxalyl dichloride; water; palladium(II) hydroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; N,N-dimethyl-formamide; methylamine; lithium hydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja405455g