3-Pyridinol,2-ethenyl-,acetate(ester)(9CI)

Base Information

• Chemical Name: 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI)
• CAS No.: 767290-23-3
• Molecular Formula: C9H9 N O2
• Molecular Weight: 163.176
• Hs Code.: 2933399090
• Mol file: 767290-23-3.mol

Synonyms:3-Pyridinol,2-ethenyl-, acetate (ester) (9CI)

Chemical Property of 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI)

Chemical Property:

• PSA: 39.19000
• LogP: 1.64990

Purity/Quality:

99% ^*data from raw suppliers

2-ethenyl-3-Pyridinol3-acetate 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI)

There total 1 articles about 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

3-HYDROXYPYRIDINE (109-00-2) + acetic anhydride (108-24-7) + acetylene (74-86-2,25067-58-7) → 3-pyridyl acetate (17747-43-2) + 3-acetoxy-2-ethenylpyridine (767290-23-3)

Guidance literature:

3-HYDROXYPYRIDINE; acetylene; With tributyl-amine; tin(IV) chloride; In chlorobenzene; at -40 - 130 ℃;

acetic anhydride; With dmap; triethylamine; at 20 ℃; for 9h;

Reference yield:

3-acetoxy-2-ethenylpyridine (767290-23-3) → C19H15BrN4O5

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 3102.97 Torr / Autoclave; Inert atmosphere

2.1: sodium methylate / methanol / 3 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C

3.2: 0.5 h / 10 °C

4.1: sulfuric acid / 20 °C

5.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C

6.1: pyridine / dichloromethane / 0 - 20 °C

With pyridine; N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; sodium hydride; potassium hydroxide; In methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml500341w

Reference yield:

3-acetoxy-2-ethenylpyridine (767290-23-3) → 1-(5-(cyclohexylmethyl)-3-((2-ethylpyridin-3-yl)oxy)pyridin-2-yl)-3-methylurea (1442670-35-0)

Guidance literature:

Multi-step reaction with 8 steps

1.1: hydrogen; palladium 10% on activated carbon / methanol / 3102.97 Torr / Autoclave; Inert atmosphere

2.1: sodium methylate / methanol / 3 h / 60 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C

3.2: 0.5 h / 10 °C

4.1: sulfuric acid / 20 °C

5.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C

6.1: pyridine / dichloromethane / 0 - 20 °C

7.1: triethylamine / dichloromethane; tetrahydrofuran

8.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / Inert atmosphere; Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; palladium diacetate; sodium hydride; triethylamine; potassium hydroxide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml500341w

upstream raw materials:

3-HYDROXYPYRIDINE

acetic anhydride

acetylene

Downstream raw materials:

3-hydroxy-2-vinylpyridine

1-(5-(cyclohexylmethyl)-3-((2-ethylpyridin-3-yl)oxy)pyridin-2-yl)-3-methylurea

Refernces