Technology Process of 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI)
There total 1 articles about 3-Pyridinol,2-ethenyl-,acetate(ester)(9CI) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-HYDROXYPYRIDINE; acetylene;
With
tributyl-amine; tin(IV) chloride;
In
chlorobenzene;
at -40 - 130 ℃;
acetic anhydride;
With
dmap; triethylamine;
at 20 ℃;
for 9h;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 3102.97 Torr / Autoclave; Inert atmosphere
2.1: sodium methylate / methanol / 3 h / 60 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C
3.2: 0.5 h / 10 °C
4.1: sulfuric acid / 20 °C
5.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C
6.1: pyridine / dichloromethane / 0 - 20 °C
With
pyridine; N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; sodium hydride; potassium hydroxide;
In
methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500341w
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: hydrogen; palladium 10% on activated carbon / methanol / 3102.97 Torr / Autoclave; Inert atmosphere
2.1: sodium methylate / methanol / 3 h / 60 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 - 10 °C
3.2: 0.5 h / 10 °C
4.1: sulfuric acid / 20 °C
5.1: N-Bromosuccinimide; potassium hydroxide / methanol; water / 0 - 100 °C
6.1: pyridine / dichloromethane / 0 - 20 °C
7.1: triethylamine / dichloromethane; tetrahydrofuran
8.1: palladium diacetate; dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane / tetrahydrofuran / Inert atmosphere; Reflux
With
dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; pyridine; N-Bromosuccinimide; sulfuric acid; palladium 10% on activated carbon; hydrogen; sodium methylate; palladium diacetate; sodium hydride; triethylamine; potassium hydroxide;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ml500341w
