methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate

Base Information

• Chemical Name: methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate
• CAS No.: 1276109-85-3
• Molecular Formula: C₁₆H₂₂N₂O₇
• Molecular Weight: 354.36
• Mol file: 1276109-85-3.mol

Synonyms:methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate

Chemical Property of methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate

There total 2 articles about methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

methyl 3-hydroxy-4-nitrobenzoate (713-52-0) + 3-bromopropylamine tert-butylcarbamate (83948-53-2) → methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate (1276109-85-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 16h;

DOI:10.1039/c9ob00123a

Reference yield:

N-tert-butoxycarbonyl-3-aminopropanol (58885-58-8) + methyl 3-hydroxy-4-nitrobenzoate (713-52-0) → methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate (1276109-85-3)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

Reference yield: 93.0%

methyl 3-(3-((tert-butoxycarbonyl)amino)propoxy)-4-nitrobenzoate (1276109-85-3) → methyl 4-amino-3-(3-((tert-butoxycarbonyl)amino)propoxy)benzoate (1276109-88-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 16h;

DOI:10.1039/c9ob00123a

upstream raw materials:

N-tert-butoxycarbonyl-3-aminopropanol

methyl 3-hydroxy-4-nitrobenzoate

3-bromopropylamine tert-butylcarbamate

Downstream raw materials:

4-acrylamido-3-(3-(tert-butoxycarbonylamino)propoxy)benzoic acid

tert-butyl 3-(2-acrylamido-5-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenoxy)propylcarbamate

N-(2-(3-aminopropoxy)-4-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenyl)acrylamide trifluoroacetate

N₁-(3-(2-acrylamido-5-(4-(2-(3-hydroxyphenyl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)-1,2,3,6-tetrahydropyridine-1-carbonyl)phenoxy)propyl)-N₅-(15-oxo-19-((3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-4,7,10-trioxa-14-azanonadecyl)glutaramide