2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

Base Information

Chemical Name:2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate
CAS No.:187160-55-0
Molecular Formula:C₁₈H₂₃N₃O₆Si
Molecular Weight:405.483
Hs Code.:

Synonyms:2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

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Chemical Property of 2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

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Technology Process of 2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

There total 8 articles about 2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 127-09-3
sodium acetate

: 187160-54-9
[(3-Nitro-benzylaminooxalyl)-amino]-acetic acid 2-trimethylsilanyl-ethyl ester

: 187160-55-0
2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

Guidance literature:: With acetic anhydride; In dichloromethane; for 48h; Heating;
DOI:10.1021/jm960594+

Reference yield:

: 2916-68-9
2-(Trimethylsilyl)ethanol

: 187160-55-0
2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 19 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature

3: 37 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 20 h / Ambient temperature

4: 42 percent / Ac₂O / CH₂Cl₂ / 48 h / Heating

With dmap; hydrogen; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm960594+

Reference yield:

: 65057-56-9
2-(trimethylsilyl)ethyl 2-(((benzyloxy)carbonyl)amino)acetate

: 187160-55-0
2-(trimethylsilyl)-ethyl 3-(3-nitrobenzyl)-2-methylidene-4,5-dioxoimidazolidine-1-acetate

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethyl acetate / 4 h / Ambient temperature

2: 37 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, DMAP / CH₂Cl₂ / 20 h / Ambient temperature

3: 42 percent / Ac₂O / CH₂Cl₂ / 48 h / Heating

With dmap; hydrogen; acetic anhydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In dichloromethane; ethyl acetate;
DOI:10.1021/jm960594+