(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

Base Information

Chemical Name:(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide
CAS No.:1220532-39-7
Molecular Formula:Br*C₁₈H₁₈N₃
Molecular Weight:356.265
Hs Code.:

Synonyms:(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

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Chemical Property of (R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

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Technology Process of (R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

There total 6 articles about (R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 55401-97-3
2-(Bromomethyl)pyridine

: 1220532-30-8
(R)-5-phenyl-6,7-dihydro-5H-pyrrolo-[1,2-c]imidazole

: 1220532-39-7
(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

Guidance literature:: In methanol; at 75 ℃; for 48h; Inert atmosphere;
DOI:10.1021/ol1003737

Reference yield:

: 102676-61-9
3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde

: 1220532-39-7
(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 18 h / -40 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 1 h / 40 °C / Inert atmosphere

3: acetonitrile / 20 h / Reflux

4: HPLC (OD-H, 2cm × 25cm) / hexane; isopropyl alcohol / Resolution of racemate

5: methanol / 48 h / Inert atmosphere

With thionyl chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; acetonitrile;

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 1220532-39-7
(R)-5-phenyl-2-(2-pyridinylmethyl)-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-2-ium bromide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrahydrofuran / 18 h / -40 - 20 °C / Inert atmosphere

2: thionyl chloride / dichloromethane / 1 h / 40 °C / Inert atmosphere

3: acetonitrile / 20 h / Reflux

4: HPLC (OD-H, 2cm × 25cm) / hexane; isopropyl alcohol / Resolution of racemate

5: methanol / 48 h / Inert atmosphere

With thionyl chloride; In tetrahydrofuran; methanol; hexane; dichloromethane; isopropyl alcohol; acetonitrile;