1H-Imidazole-4-propanal, 1-(triphenylmethyl)-

Base Information

• Chemical Name: 1H-Imidazole-4-propanal, 1-(triphenylmethyl)-
• CAS No.: 102676-61-9
• Molecular Formula: C25H22N2O
• Molecular Weight: 366.462
• DSSTox Substance ID: DTXSID50466354
• Nikkaji Number: J1.305.536J
• Wikidata: Q82292904
• Mol file: 102676-61-9.mol

Synonyms:102676-61-9;3-(1-tritylimidazol-4-yl)propanal;1H-Imidazole-4-propanal, 1-(triphenylmethyl)-;3-(1-TRITYLIMIDAZOL-4-YL)PROPIONALDEHYDE;3-(1-trityl-1H-imidazol-4-yl)propanal;3-[1-(triphenylmethyl)-1H-imidazol-4-yl]propanal;SCHEMBL1040511;DTXSID50466354;YLOUDHXZAFVYCU-UHFFFAOYSA-N;CEA67661;MFCD04039710;AKOS025402645;AM804768;AS-66623;-3(1-Tritylimidazol-4-Yl)Propionaldehyde;CS-0318889;3-(1-trityl-1H-imidazol-4-yl)propionaldehyde;3-(1-triphenylmethyl-1H-imidazol-4-yl)propanal;3-(1-triphenylmethyl-1H-imidazole-4-yl)propanal;3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde;A880687

Chemical Property of 1H-Imidazole-4-propanal, 1-(triphenylmethyl)-

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 7
• Exact Mass: 366.173213330
• Heavy Atom Count: 28
• Complexity: 429

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C=C(N=C4)CCC=O

Technology Process of 1H-Imidazole-4-propanal, 1-(triphenylmethyl)-

There total 14 articles about 1H-Imidazole-4-propanal, 1-(triphenylmethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

oxalyl dichloride (79-37-8) + 3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde (102676-61-9)

Guidance literature:

With triethylamine; In 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; dimethyl sulfoxide;

Reference yield: 78.0%

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol (152030-49-4) → 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde (102676-61-9)

Guidance literature:

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -60 - 20 ℃; for 2h;

DOI:10.1016/j.bmc.2005.09.002

Reference yield: 51.0%

3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester (102676-60-8) → 3-(1-triphenylmethyl-4-imidazolyl)propionaldehyde (102676-61-9)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; toluene; at -72 ℃; for 0.0833333h;

DOI:10.1021/jm00106a038

upstream raw materials:

3-(1-triphenylmethyl-1H-imidazol-4-yl)propanoic acid methyl ester

3-(1-trityl-1H-imidazol-4-yl)propan-1-ol

trityl chloride

trans-4-imidazoleacrylic acid methyl ester hydrochloride

Downstream raw materials:

ethyl 5-<1-(triphenylmethyl)-1H-imidazol-4-yl>-1-pent-2-enoate

4-<3-<4-<(tert-butylamino)carbonyl>phenyl>-3-hydroxyprop-1-yl>-1-(triphenylmethyl)-1H-imidazole

4-(4,4-dibromobut-3-enyl)-1-(triphenylmethyl)imidazole

tert-butyl (1-((((4-chlorobenzyl)amino)sulfonyl)methyl)-3-(1-(triphenylmethyl) imidazol-4-yl)propyl) carbonate