4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

Base Information

Chemical Name:4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one
CAS No.:795266-61-4
Molecular Formula:C₁₉H₁₇ClF₂N₄O
Molecular Weight:390.82
Hs Code.:

Synonyms:4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

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Chemical Property of 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

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Technology Process of 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

There total 10 articles about 4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1395552-94-9
2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

: 795266-61-4
4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

Guidance literature:: 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine; With hydrogen bromide; In water; at 80 ℃;

With sodium hydrogencarbonate; In water; ethyl acetate; at 20 ℃;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 123148-66-3
2-methoxy-4-(hydroxymethyl)-pyridine

: 795266-61-4
4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 2.25 h / 0 °C

2.1: 18-crown-6 ether / acetonitrile / 13 h / 20 °C

3.1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

4.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

5.1: hydrogen bromide / water / 80 °C

5.2: 20 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; thionyl chloride; 18-crown-6 ether; hydrogen bromide; hydrogen; potassium carbonate; In ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 795266-61-4
4-(2-{[2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidin-4-yl]amino}ethyl)pyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,4-dioxane / 26 h / Reflux

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: thionyl chloride / 2.25 h / 0 °C

4.1: 18-crown-6 ether / acetonitrile / 13 h / 20 °C

5.1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

6.1: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

7.1: hydrogen bromide / water / 80 °C

7.2: 20 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; hydrogen bromide; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; water; acetonitrile;
DOI:10.1016/j.bmc.2012.06.049