2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

Base Information

Chemical Name:2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine
CAS No.:1395552-94-9
Molecular Formula:C₂₀H₁₉ClF₂N₄O
Molecular Weight:404.847
Hs Code.:

Synonyms:2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

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Chemical Property of 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

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Technology Process of 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

There total 10 articles about 2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 764648-59-1
4-chloro-2-(4-chloro-2,5-difluorophenyl)-6-ethylpyrimidine

: 764708-27-2
2-(2-methoxypyridin-4-yl)ethylamine

: 1395552-94-9
2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

Guidance literature:: With 1,3-dimethyl-2-imidazolidinone; potassium carbonate; at 80 ℃;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 58481-11-1
methyl 2-chloroisonicotinate

: 1395552-94-9
2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1: 1,4-dioxane / 26 h / Reflux

2: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3: thionyl chloride / 2.25 h / 0 °C

4: 18-crown-6 ether / acetonitrile / 13 h / 20 °C

5: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

6: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; hydrogen; potassium carbonate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.06.049

Reference yield:

: 2-(2-methoxypyridin-4-yl)acetonitrile

: 1395552-94-9
2-(4-chloro-2,5-difluorophenyl)-6-ethyl-N-[2-(2-methoxypyridin-4-yl)ethyl]pyrimidin-4-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; ammonium hydroxide / ethanol / 22 h / 20 °C

2: 1,3-dimethyl-2-imidazolidinone; potassium carbonate / 80 °C

With 1,3-dimethyl-2-imidazolidinone; ammonium hydroxide; hydrogen; potassium carbonate; In ethanol;
DOI:10.1016/j.bmc.2012.06.049