2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Base Information

Chemical Name:2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione
CAS No.:1356352-75-4
Molecular Formula:C₁₇H₁₄F₃N₃O₄
Molecular Weight:381.311
Hs Code.:

Synonyms:2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Chemical Property of 2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

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Technology Process of 2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

There total 10 articles about 2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356353-37-1
2-(methylsulfanyl)-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

: 141-52-6
sodium ethanolate

: 1356352-75-4
2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: In ethanol; for 3h; Reflux;

Reference yield:

: 1356353-33-7
methyl 6-chloro-2-[(4-methoxybenzyl)amino]pyridine-3-carboxylate

: 1356352-75-4
2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: trifluoroacetic acid / 2 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

2.3: 0.5 h / Reflux

3.1: sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1 h / 60 °C

4.1: pyridine hydrochloride / N,N-dimethyl-formamide / 2 h / 120 °C

5.1: ethanol / 3 h / Reflux

With pyridine hydrochloride; sodium hydride; sodium hydrogencarbonate; trifluoroacetic acid; In ethanol; water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 849805-25-0
methyl 2-amino-6-chloropyridine-3-carboxylate

: 1356352-75-4
2-ethoxy-3-[4-(2,2,2-trifluoroethoxy)phenyl]pyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / Cooling with ice

1.3: 0.5 h / Reflux

2.1: sodium hydrogencarbonate / N,N-dimethyl-formamide; water / 1 h / 60 °C

3.1: pyridine hydrochloride / N,N-dimethyl-formamide / 2 h / 120 °C

4.1: ethanol / 3 h / Reflux

With pyridine hydrochloride; sodium hydride; sodium hydrogencarbonate; In ethanol; water; N,N-dimethyl-formamide; mineral oil;