2-Pyrrolidinone,1-(3-hydroxypropyl)-5-methyl-(9CI)

Base Information

• Chemical Name: 2-Pyrrolidinone,1-(3-hydroxypropyl)-5-methyl-(9CI)
• CAS No.: 764718-04-9
• Molecular Formula: C₈H₁₅NO₂
• Molecular Weight: 157.213
• Mol file: 764718-04-9.mol

Synonyms:5-Methyl-N-(3-hydroxypropyl)-2-pyrrolidone

Chemical Property of 2-Pyrrolidinone,1-(3-hydroxypropyl)-5-methyl-(9CI)

Chemical Property:

• PSA: 40.54000
• LogP: 0.31760

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pyrrolidinone,1-(3-hydroxypropyl)-5-methyl-(9CI)

There total 4 articles about 2-Pyrrolidinone,1-(3-hydroxypropyl)-5-methyl-(9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

levulinic acid (123-76-2) + propan-1-ol-3-amine (156-87-6) → 1-(3-hydroxypropyl)-5-methylpyrrolidin-2-one (764718-04-9)

Guidance literature:

With platinum on carbon; hydrogen; In methanol; at 25 ℃; for 3h;

DOI:10.1021/jacs.8b13024

Reference yield: 90.0%

4-oxopentanoic acid ethyl ester (539-88-8) + propan-1-ol-3-amine (156-87-6) → 1-(3-hydroxypropyl)-5-methylpyrrolidin-2-one (764718-04-9)

Guidance literature:

With platinum doped titanium oxide; hydrogen; In neat (no solvent); at 120 ℃; for 2h; under 7500.75 Torr; chemoselective reaction;

DOI:10.1021/acscatal.5b01113

Reference yield:

C10H19NO3 → 1-(3-hydroxypropyl)-5-methylpyrrolidin-2-one (764718-04-9)

Guidance literature:

With hydrogen; In neat (no solvent); at 85 ℃; for 12h; under 760.051 Torr; Green chemistry;

DOI:10.1039/c9gc00396g

upstream raw materials:

levulinic acid

propan-1-ol-3-amine

4-oxopentanoic acid ethyl ester

Refernces

• 1、 Muzzio, Michelle,Yu, Chao,Lin, Honghong,Yom, Typher,Boga, Dilek A.,Xi, Zheng,Li, Na,Yin, Zhouyang,Li, Junrui,Dunn, Joshua A.,Sun, Shouheng. "Reductive amination of ethyl levulinate to pyrrolidones over AuPd nanoparticles at ambient hydrogen pressure". . p. 1895 - 1899. Retrieved 2019/04/29.
• 2、 -. "Production of 5-mehyl-N-aryl-2-pyrrolidone and 5-methyl-N-alkyl-2-pyrrolidone by reductive of levulinic acid esters with aryl and alkyl amines". Page 11. . Retrieved 2008/06/13.