2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile

Base Information

Chemical Name:2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile
CAS No.:764651-70-9
Molecular Formula:C₁₀H₁₃N₃
Molecular Weight:175.233
Hs Code.:2933399090
DSSTox Substance ID:DTXSID601232490
Mol file:764651-70-9.mol

Synonyms:764651-70-9;2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile;2-[6-(DIMETHYLAMINO)-4-METHYLPYRIDIN-3-YL]ACETONITRILE;(6-Dimethylamino-4-methyl-pyridin-3-yl)-acetonitrile;SCHEMBL1237258;DTXSID601232490;AMY17280;AKOS006289292;F82000;6-(Dimethylamino)-4-methyl-3-pyridineacetonitrile;A927962

Suppliers and Price of 2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile 95+%
1g
$ 772.00

Chemenu
2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile 95%
1g
$ 729.00

American Custom Chemicals Corporation
6-(DIMETHYLAMINO)-4-METHYLNICOTINONITRILE 95.00%
1G
$ 842.87

Alichem
2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile
1g
$ 795.60

Total 7 raw suppliers

Chemical Property of 2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile

Chemical Property:

Vapor Pressure:2.04E-05mmHg at 25°C
Refractive Index:1.545
Boiling Point:361.7°C at 760 mmHg
Flash Point:172.5°C
PSA：39.92000
Density:1.08g/cm³
LogP:1.52208
Storage Temp.:Inert atmosphere,Room Temperature
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:175.110947427
Heavy Atom Count:13
Complexity:204

Purity/Quality:

97% ^*data from raw suppliers

2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC(=NC=C1CC#N)N(C)C

Technology Process of 2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile

There total 3 articles about 2-(6-(Dimethylamino)-4-methylpyridin-3-yl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 38622-91-2,36635-61-7
[(p-methylphenyl)sulfonylmethyl]isonitrile

: 764651-69-6
2-dimethylamino-4-methyl-5-formylpyridine

: 764651-70-9
2-dimethylamino-4-methyl-5-(cyanomethyl)pyridine

Guidance literature:: [(p-methylphenyl)sulfonylmethyl]isonitrile; With potassium tert-butylate; In 1,2-dimethoxyethane; at -50 ℃; for 0.166667h;

2-dimethylamino-4-methyl-5-formylpyridine; In 1,2-dimethoxyethane; at -50 ℃; for 0.5h;
DOI:10.1021/jm040058e

Reference yield:

: 20173-72-2
2-(N,N-dimethylamino)-4-methylpyridine

: 764651-70-9
2-dimethylamino-4-methyl-5-(cyanomethyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: Br₂; aq. Na₂CO₃ / CH₂Cl₂ / 0.5 h / 0 °C

2.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h

2.2: 77 percent / tetrahydrofuran / 20 °C

3.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C

3.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C

With potassium tert-butylate; bromine; sodium carbonate; magnesium; ethylene dibromide; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane;
DOI:10.1021/jm040058e

Reference yield:

: 764651-68-5
5-bromo-2-dimethylamino-4-methylpyridine

: 764651-70-9
2-dimethylamino-4-methyl-5-(cyanomethyl)pyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 0.5 h

1.2: 77 percent / tetrahydrofuran / 20 °C

2.1: KOtBu / 1,2-dimethoxy-ethane / 0.17 h / -50 °C

2.2: 80 percent / 1,2-dimethoxy-ethane / 0.5 h / -50 °C

With potassium tert-butylate; magnesium; ethylene dibromide; In tetrahydrofuran; 1,2-dimethoxyethane;
DOI:10.1021/jm040058e