benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

Base Information

Chemical Name:benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate
CAS No.:1189798-00-2
Molecular Formula:C₂₆H₂₀N₄O₄
Molecular Weight:452.469
Hs Code.:

Synonyms:benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

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Chemical Property of benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

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Technology Process of benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

There total 7 articles about benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 1189797-63-4
9-bromo-2-(4-methylphenyl)-2,6-dihydro[1,2,4]triazolo-[4,3-c]quinazoline-3,5-dione

: 2495-35-4,25036-21-9
benzylacrylate

: 1189798-00-2
benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

Guidance literature:: With palladium diacetate; triethylamine; triphenylphosphine; In N,N-dimethyl-formamide; at 120 ℃; for 15h; Sealed tube; Inert atmosphere;
DOI:10.1016/j.bmc.2010.11.050

Reference yield:

: 49681-94-9
6-Methyl-4-oxo-2-thioxo-1,2,3,4-tetrahydrochinazolin

: 1189798-00-2
benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium methylate / methanol; N,N-dimethyl-formamide / 0.25 h / 20 °C

1.2: 22 h / 20 °C

2.1: iodine; triphenylphosphine / toluene / 0.25 h / 95 °C

2.2: 0.83 h / 95 °C

3.1: N-ethyl-N,N-diisopropylamine / 60 h / 110 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

4.2: 0.5 h

5.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 15 h / 120 °C / Sealed tube; Inert atmosphere

With iodine; sodium methylate; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; palladium diacetate; triphenylphosphine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1189797-84-9
9-bromo-2-(4-methylphenyl)-5-(methylsulfanyl)[1,2,4]-triazolo[4,3-c]quinazolin-3(2H)-one

: 1189798-00-2
benzyl (2E)-3-[2-(4-methylphenyl)-3,5-dioxo-2,6-dihydro-[1,2,4]triazolo[4,3-c]quinazolin-9-yl]acrylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 6 h / 20 °C

1.2: 0.5 h

2.1: triethylamine / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 15 h / 120 °C / Sealed tube; Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; palladium diacetate; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;