Technology Process of 3-nitro-2,6-diphenylpyridine-1-oxide
There total 3 articles about 3-nitro-2,6-diphenylpyridine-1-oxide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-nitro-2-phenylpyridine N-oxide; phenylmagnesium bromide;
In
tetrahydrofuran;
at -60 ℃;
Inert atmosphere;
With
2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran;
at -60 - 20 ℃;
Inert atmosphere;
DOI:10.1021/ol202597b
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: palladium on activated charcoal; sodium carbonate / 1,2-dimethoxyethane; water / 9 h / 80 °C
2.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
3.1: tetrahydrofuran / -60 °C / Inert atmosphere
3.2: -60 - 20 °C / Inert atmosphere
With
palladium on activated charcoal; carbamide peroxide; sodium carbonate; trifluoroacetic anhydride;
In
tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1021/ol202597b
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: carbamide peroxide; trifluoroacetic anhydride / dichloromethane / 0 - 20 °C
2.1: tetrahydrofuran / -60 °C / Inert atmosphere
2.2: -60 - 20 °C / Inert atmosphere
With
carbamide peroxide; trifluoroacetic anhydride;
In
tetrahydrofuran; dichloromethane;
DOI:10.1021/ol202597b
