Ac-LYRANF-SCH₂CH₂COOEt

Base Information

• Chemical Name: Ac-LYRANF-SCH₂CH₂COOEt
• CAS No.: 1034403-66-1
• Molecular Formula: C₄₄H₆₄N₁₀O₁₁S
• Molecular Weight: 941.119
• Mol file: 1034403-66-1.mol

Synonyms:Ac-LYRANF-SCH₂CH₂COOEt

Chemical Property of Ac-LYRANF-SCH₂CH₂COOEt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ac-LYRANF-SCH₂CH₂COOEt

There total 2 articles about Ac-LYRANF-SCH₂CH₂COOEt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

3-mercaptopropionic acid ethyl ester (5466-06-8) + Fmoc-Leu-OH (35661-60-0) + N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine (35661-39-3,136132-75-7) + N-Fmoc L-Phe (35661-40-6) + Fmoc-Tyr(tBu)-OH (71989-38-3,118488-18-9,204384-67-8) + L-Asn(Trt) (132388-59-1) + Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine (187618-60-6) → Ac-LYRANF-SCH2CH2COOEt (1034403-66-1)

Guidance literature:

N-Fmoc L-Phe; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 16h;

With piperidine; In N,N-dimethyl-formamide;

3-mercaptopropionic acid ethyl ester; Fmoc-Leu-OH; N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine; Fmoc-Tyr(tBu)-OH; L-Asn(Trt); Nα-(9-fluorenylmethyloxycarbonyl)-Nγ-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine; acetylated derivative; Further stages;

DOI:10.1021/ja502806r

Reference yield:

C61H87N10O14PolS2 → Ac-LYRANF-SCH2CH2COOEt (1034403-66-1)

Guidance literature:

With chlorotriisopropylsilane; methyl-phenyl-thioether; water; trifluoroacetic acid; for 2h; solid phase reaction;

DOI:10.1002/chem.200701978

Reference yield: 84.0%

H-Asp-Ser-Pro-Gly-Tyr-Ser-NH2 (1044284-90-3) + Ac-LYRANF-SCH2CH2COOEt (1034403-66-1) → Ac-LYRANFDSPGYS-NH2 (1320358-59-5)

Guidance literature:

With guanidine hydrochloride; thiophenol; N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid; In N-methyl-2-pyrrolidinone; water; at 37 ℃; for 96h; pH=7.5;

DOI:10.1021/ol2017356

upstream raw materials:

3-mercaptopropionic acid ethyl ester

Fmoc-Leu-OH

N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-alanine

N-Fmoc L-Phe

Downstream raw materials:

C₆₄H₉₂N₁₇O₂₂P

C₆₅H₉₄N₁₇O₂₂P

Ac-LYRANFESPGYS-NH₂

Ac-LYRANFDSPGYS-NH₂