ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

• Chemical Name: ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS No.: 749906-87-4
• Molecular Formula: C₁₄H₁₄BrClN₂O₃
• Molecular Weight: 373.634
• Mol file: 749906-87-4.mol

Synonyms:ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property of ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 3 articles about ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (5948-71-0) → ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (749906-87-4)

Guidance literature:

With dioxane dibromide; In 1,4-dioxane; at 20 ℃; for 5h;

DOI:10.1080/00397910802654682

Reference yield:

4-chlorobenzaldehyde (104-88-1) → ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (749906-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / acetonitrile / 70 - 75 °C / Sonication

2: bromine / chloroform / 12 h

With tin(II) chloride dihdyrate; bromine; In chloroform; acetonitrile; 1: |Biginelli Pyrimidone Synthesis;

DOI:10.1016/j.bioorg.2018.05.026

Reference yield:

ethyl acetoacetate (141-97-9) → ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (749906-87-4)

Guidance literature:

Multi-step reaction with 2 steps

1: tin(II) chloride dihdyrate / acetonitrile / 70 - 75 °C / Sonication

2: bromine / chloroform / 12 h

With tin(II) chloride dihdyrate; bromine; In chloroform; acetonitrile; 1: |Biginelli Pyrimidone Synthesis;

DOI:10.1016/j.bioorg.2018.05.026

upstream raw materials:

4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

4-chlorobenzaldehyde

ethyl acetoacetate

Downstream raw materials:

C₂₀H₁₉ClN₂O₅S

ethyl 4-(4-chlorophenyl)-2-oxo-6-(tosylmethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate

ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate