ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate
CAS No.:1446846-45-2
Molecular Formula:C₁₄H₁₆ClN₃O₃
Molecular Weight:309.752
Hs Code.:

Synonyms:ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

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Technology Process of ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

There total 5 articles about ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 749906-87-4
ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1446846-45-2
ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Guidance literature:: With ammonium acetate; In dimethyl sulfoxide; at 45 - 50 ℃; for 0.583333h;
DOI:10.1016/j.bioorg.2018.05.026

Reference yield: 56.0%

: 1199944-26-7
ethyl 6-(azidomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 1446846-45-2
ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethanol; Reflux;
DOI:10.1080/00397911.2012.707738

Reference yield:

: 5948-71-0
4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one

: 1446846-45-2
ethyl-6-(aminomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: bromine / chloroform / 12 h

2: ammonium acetate / dimethyl sulfoxide / 0.58 h / 45 - 50 °C

With ammonium acetate; bromine; In chloroform; dimethyl sulfoxide;
DOI:10.1016/j.bioorg.2018.05.026