4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Base Information

• Chemical Name: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester
• CAS No.: 5948-71-0
• Molecular Formula: C14H15ClN2O3
• Molecular Weight: 294.738
• Mol file: 5948-71-0.mol

Synonyms:4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property of 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 213-215 °C
• Refractive Index: 1.548
• Boiling Point: 411.782°C at 760 mmHg
• PKA: 11.16±0.70(Predicted)
• Flash Point: 202.839°C
• PSA: 67.43000
• Density: 1.257g/cm³
• LogP: 3.18860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl4-(4-chlorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in Laboratory research and development process and chemical production process.

Technology Process of 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester

There total 20 articles about 4-(4-Chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl acetoacetate (141-97-9) + 4-chlorobenzaldehyde (104-88-1) + urea (57-13-6) → 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (5948-71-0)

Guidance literature:

With copper(II) bis(trifluoromethanesulfonate); In ethanol; at 100 ℃; for 1h; Microwave irradiation; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.10.150

Reference yield: 98.0%

(acetyloxy)(4-chlorophenyl)methyl acetate (13086-93-6) + ethyl acetoacetate (141-97-9) + urea (57-13-6) → 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (5948-71-0)

Guidance literature:

With bismuth(III) vanadate; In neat (no solvent); at 120 ℃; for 0.75h; Green chemistry;

DOI:10.1007/s13738-016-0959-y

Reference yield: 96.0%

4-chlorobenzaldehyde semicarbazone (5315-86-6,94794-23-7) + ethyl acetoacetate (141-97-9) + thiourea (17356-08-0) → 4-(4-chlorophenyl)-5-(ethoxycarbonyl)-6-methyl-3,4-dihydropyrimidin-2(1H)-one (5948-71-0)

Guidance literature:

With bismuth(III) vanadate; In ethanol; for 1.16667h; Reflux;

DOI:10.1007/s13738-016-0959-y

upstream raw materials:

ethyl acetoacetate

4-chlorobenzaldehyde

urea

1-Chloro-4-(chloromethyl)benzene

Downstream raw materials:

4-(4-chloro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid hydrazide

ethyl 4-(4-chlorophenyl)-1,2-dihydro-6-methyl-2-oxopyrimidine-5-carboxylate

ethyl-6-(bromomethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

C₁₄H₁₃ClN₂O₃

Refernces

• 1、 Rezayati, Sobhan,Kalantari, Fatemeh,Ramazani, Ali,Sajjadifar, Sami,Aghahosseini, Hamideh,Rezaei, Aram. "Magnetic Silica-Coated Picolylamine Copper Complex [Fe3O4@SiO2@GP/Picolylamine-Cu(II)]-Catalyzed Biginelli Annulation Reaction". . p. 992 - 1010. Retrieved 2022/01/11.
• 2、 Li, Yancong,Ma, Jiliang,Liu, Zhendong,Jin, Dongnv,Jiao, Gaojie,Guo, Yanzhu,Wang, Qiang,Zhou, Jinghui,Sun, Runcang. "Fabrication of porous ultrathin carbon nitride nanosheet catalysts with enhanced photocatalytic activity for N- And O-heterocyclic compound synthesis". . p. 365 - 372. Retrieved 2021/01/11.