(S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile

Base Information

• Chemical Name: (S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile
• CAS No.: 604808-45-9
• Molecular Formula: C₁₃H₁₈NO₅P
• Molecular Weight: 299.263
• Mol file: 604808-45-9.mol

Synonyms:(S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile

Chemical Property of (S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile

There total 1 articles about (S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

diethyl cyanophosphonate (2942-58-7) + 4-methoxy-benzaldehyde (123-11-5) → (S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile (604808-45-9)

Guidance literature:

(S)-1,1'-di(2-hydroxy-3-((diethylamino)methyl)naphthyl)*AlCl; In hexane; toluene; at 20 ℃; for 10h;

DOI:10.1002/anie.200351552

Reference yield:

(S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile (604808-45-9) → (R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol (46084-23-5)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 12h;

DOI:10.1002/chem.200401290

Reference yield:

(S)-2-(diethylphosphoryloxy)-2-(4-methoxyphenyl)acetonitrile (604808-45-9) → N-(2-hydroxy-2(4-methoxyphenyl)ethyl)-3-phenyl-2-propenamide

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 12 h / 0 °C

2: tetrahydrofuran / 6 h

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1002/chem.200401290

upstream raw materials:

diethyl cyanophosphonate

4-methoxy-benzaldehyde

Downstream raw materials:

(R)-(-)-2-Amino-1-(4-methoxyphenyl)-1-ethanol

(R)-(-)-N-(2-hydroxy-2-(4-methoxyphenyl)ethyl)benzamide