[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

Base Information

Chemical Name:[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone
CAS No.:1246531-29-2
Molecular Formula:C₂₈H₃₃N₉O₂
Molecular Weight:527.629
Hs Code.:

Synonyms:[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

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Chemical Property of [4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

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Technology Process of [4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

There total 5 articles about [4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-98-6
2-Picolinic acid

: 1246532-95-5
N₆-cyclohexyl-N₂-(2-methoxy-4-piperazin-1-yl-phenyl)-9H-purine-2,6-diamine

: 1246531-29-2
[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

: 39639-45-7
(2-chloro-9H-purin-6-yl)-cyclohexyl-amine

: 1246531-29-2
[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / Reflux

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C

3: hydrogenchloride / 1,4-dioxane; methanol

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; palladium diacetate; benzotriazol-1-ol; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 2: Buchwald coupling;
DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

: 1017782-79-4
tert-butyl 4-(3-methoxy-4-nitrophenyl)piperazine-1-carboxylate

: 1246531-29-2
[4-(4-{[6-(cyclohexylamino)-9H-purin-2-yl]amino}-3-methoxyphenyl)piperazin-1-yl](pyridin-2-yl)methanone

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 90 °C

3: hydrogenchloride / 1,4-dioxane; methanol

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; benzotriazol-1-ol; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide; toluene; 2: Buchwald coupling;
DOI:10.1016/j.bmcl.2012.04.131