2-acetyl-3-fluorophenyl acetate

Base Information

• Chemical Name: 2-acetyl-3-fluorophenyl acetate
• CAS No.: 1408087-54-6
• Molecular Formula: C₁₀H₉FO₃
• Molecular Weight: 196.178
• Mol file: 1408087-54-6.mol

Synonyms:2-acetyl-3-fluorophenyl acetate

Chemical Property of 2-acetyl-3-fluorophenyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-acetyl-3-fluorophenyl acetate

There total 5 articles about 2-acetyl-3-fluorophenyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

acetyl chloride (75-36-5) + 1-(2-fluoro-6-hydroxyphenyl)ethan-1-one (93339-98-1) → 2-acetyl-3-fluorophenyl acetate (1408087-54-6)

Guidance literature:

With pyridine; In dichloromethane; at 45 ℃; for 3h; Cooling with ice;

Reference yield:

2-fluoro-6-methoxybenzaldehyde (146137-74-8) → 2-acetyl-3-fluorophenyl acetate (1408087-54-6)

Guidance literature:

Multi-step reaction with 4 steps

1.1: magnesium / diethyl ether / 12 h / 20 °C

1.2: 0 °C

2.1: dipyridinium dichromate / N,N-dimethyl-formamide / 12 h / 20 °C

3.1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C

4.1: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

With pyridine; aluminum (III) chloride; dipyridinium dichromate; magnesium; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-(2-Fluoro-6-methoxyphenyl)ethanone (120484-50-6) → 2-acetyl-3-fluorophenyl acetate (1408087-54-6)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 12 h / 20 °C

2: pyridine / dichloromethane / 3 h / 45 °C / Cooling with ice

With pyridine; aluminum (III) chloride; In dichloromethane;

upstream raw materials:

acetyl chloride

1-(2-fluoro-6-hydroxyphenyl)ethan-1-one

1-(2-Fluoro-6-methoxyphenyl)ethanone

2-fluoro-6-methoxybenzaldehyde

Downstream raw materials:

2-((4-Amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(3-fluorophenyl)-5-methoxy-4H-chromen-4-one

2-((4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

2-((4-amino-3-(3-fluoro-5-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

2-((4-amino-3-(3-fluoro-5-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one

Refernces

• 1、 -. "NOVEL COMPOUNDS AS MODULATORS OF PROTEIN KINASES". Page/Page column 100. . Retrieved 2012/12/13.