1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine

Base Information

• Chemical Name: 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine
• CAS No.: 129157-07-9
• Molecular Formula: C₁₈H₂₆N₂O₃
• Molecular Weight: 318.416
• Mol file: 129157-07-9.mol

Synonyms:1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine

Chemical Property of 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine

There total 1 articles about 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (R)-phenylglycine (875-74-1) → 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine (129157-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / tetrahydrofuran; water

2: 1,1'-carbonyldiimidazole / tetrahydrofuran

With 1,1'-carbonyldiimidazole; sodium hydroxide; In tetrahydrofuran; water;

DOI:10.1016/j.tet.2019.130469

Reference yield: 95.0%

1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine (129157-07-9) → (R)-1-(2-phenylglycyl)piperidine (129157-30-8)

Guidance literature:

With trifluoroacetic acid; for 0.5h;

DOI:10.1016/S0040-4020(01)81078-4

Reference yield:

1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine (129157-07-9) → (R)-N-isopropyl-1-phenyl-2-(1-piperidino)ethylamine (129157-10-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / CF₃CO₂H / 0.5 h

2: 90 percent / NaBH₃CN / methanol; acetic acid / Ambient temperature

3: 82 percent / LiAlH₄ / tetrahydrofuran / Ambient temperature

With lithium aluminium tetrahydride; sodium cyanoborohydride; trifluoroacetic acid; In tetrahydrofuran; methanol; acetic acid;

DOI:10.1016/S0040-4020(01)81078-4

upstream raw materials:

di-tert-butyl dicarbonate

(R)-phenylglycine

Downstream raw materials:

(R)-1-(2-phenylglycyl)piperidine

(R)-N-isopropyl-1-phenyl-2-(1-piperidino)ethylamine

1-((R)-2-isopropylamino-2-phenylethanoyl)piperidine

(R)-(-)-1-(2-amino-2-phenylethyl)piperidine