129157-10-4

Usage

General Description

The chemical (R)-(+)-N-ISOPROPYL-1-PHENYL-2-(1-PIPERIDINO)ETHYLAMINE, also known as (R)-(+)-IPH, is a psychoactive substance that acts as a stimulant and an entactogen. It is a chiral compound, meaning it has a non-superimposable mirror image, and the (R)-(+) form is typically more potent and sought after. (R)-(+)-IPH has been used recreationally for its euphoric and empathogenic effects, but it also has potential therapeutic applications for conditions such as depression and anxiety. However, its use is associated with significant health risks, including addiction, cardiovascular complications, and neurotoxicity. As a result, (R)-(+)-IPH is a controlled substance in many jurisdictions and its use is heavily regulated.

InChI:InChI=1/C16H26N2/c1-14(2)17-16(15-9-5-3-6-10-15)13-18-11-7-4-8-12-18/h3,5-6,9-10,14,16-17H,4,7-8,11-13H2,1-2H3/t16-/m0/s1

Upstream product

• 110-89-4 piperidine 
• 129157-07-9 1-<(R)-2-(t-butoxycarbonylamino)-2-phenylethanoyl>piperidine 
• 33125-05-2 Boc-D-Phg-OH 
• 156000-82-7 (R)-1-piperidine 
• 129157-30-8 (R)-1-(2-phenylglycyl)piperidine 
• 17609-52-8 Z-D-phenylglycine 
• 20780-53-4 (R)-Styrene oxide 
• 40116-77-6 (R)-1-phenyl-2-(1-piperidinyl)ethanol 
• 75-31-0 isopropylamine 
• 142950-82-1 (R)-(-)-1-(2-amino-2-phenylethyl)piperidine 
• 67-64-1 acetone 
• 129176-84-7 1-((R)-2-isopropylamino-2-phenylethanoyl)piperidine 

Relevant academic research and scientific papers

Practical one-step synthesis of Koga's chiral bases

A simple, efficient and practical method for the preparation of Koga's chiral bases is described. The method involves attack of an amine on a styrene oxide-derived aziridinium ion and has allowed the synthesis of novel diamines which cannot be prepared us

Stereoselective reactions, 25. Enantioselective deprotonation of prochiral 4-substituted cyclohexanones by chiral chelated lithium amides

Enantioselective deprotonation of prochiral 4-substituted cyclohexanones (4a-d) by chiral chelated lithium amides (8a-k) in the presence of excess trimethylsilyl chloride was realized to give the corresponding chiral silyl enol ethers (6a-d) in up to 89% ee. It is shown that enantioselectivity of the reaction is dependent on the solvent used, but becomes almost independent on the solvent in the presence of HMPA. The sense of asymmetric induction can be correlated to the configuration at the chiral carbon bearing amide nitrogen of the lithium amide.

Stereoselective reactions. XXII. Design and synthesis of chiral chelated lithium amides for enantioselective reactions

Chiral chelated lithium amides ((R))-1a-g) were designed and synthesized in optically pure forms starting from (R)-phenylglycine.

ENANTIOSELECTIVE SYNTHESIS OF β-HYDROXY-α-METHYL CARBONYL COMPOUNDS BY ALDOL REACTION

The enantioselective aldol reactions of ketone lithium enolates with aldehydes mediated chiral lithium amides were extensively investigated.The chiral amino ethers 4a-4l and diamines 16a,b were prepared from α-amino acids.The reaction conditions and the s