[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

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Chemical Name:[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester
CAS No.:1340592-13-3
Molecular Formula:C₂₀H₂₃FN₄O₂
Molecular Weight:370.427
Hs Code.:

Synonyms:[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

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Chemical Property of [1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

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Technology Process of [1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

There total 6 articles about [1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1340592-12-2
1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester

: 75-65-0
tert-butyl alcohol

: 1340592-13-3
[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

Guidance literature:: 1-ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid ethyl ester; With water; sodium hydroxide; In tetrahydrofuran; ethanol; at 50 ℃; for 3h;

With hydrogenchloride; In tetrahydrofuran; ethanol; water; at 20 ℃; pH=3;

tert-butyl alcohol; With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 60 ℃; for 7h;

Reference yield:

: 1340592-14-4
1-ethyl-4-(4-fluoro-2-methylphenyl)-1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid

: 75-65-0
tert-butyl alcohol

: 1340592-13-3
[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

Guidance literature:: With diphenyl phosphoryl azide; triethylamine; In tetrahydrofuran; at 60 ℃; for 7h;

Reference yield:

: 30720-25-3
ethyl 4-chloro-1-ethyl-1H-pyrazolo[3,4-b]pyridine-5-carboxylate

: 1340592-13-3
[1-Ethyl-4-(4-fluoro-2-methyl-phenyl)-1H-pyrazolo[3,4-b]pyridin-5-yl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 15 h / 70 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol; tetrahydrofuran / 3 h / 50 °C

2.2: pH 3

3.1: triethylamine; diphenyl phosphoryl azide / tetrahydrofuran / 7 h / 60 °C

With diphenyl phosphoryl azide; water; sodium carbonate; triethylamine; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; water; toluene; 1.1: Suzuki Coupling;