{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Base Information

Chemical Name:{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile
CAS No.:1414805-52-9
Molecular Formula:C₁₂H₁₆ClN₅
Molecular Weight:265.746
Hs Code.:

Synonyms:{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Suppliers and Price of {2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of {2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

There total 7 articles about {2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 1414805-51-8
{2-(1r,4r)-4-[(2-chloro-5-nitropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

: 1414805-52-9
{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Guidance literature:: {2-(1r,4r)-4-[(2-chloro-5-nitropyrimidin-4-yl)amino]cyclohexyl}acetonitrile; With tin(II) chloride dihdyrate; In ethanol; for 2h; Reflux;

With sodium hydroxide; In water; pH=9;

Reference yield:

: 1607590-17-9
trans-[4-(cyanomethyl)cyclohexyl]ammonium trifluoroacetate

: 49845-33-2
2,4-Dichloro-5-nitropyrimidine

: 1414805-52-9
{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Guidance literature:: trans-[4-(cyanomethyl)cyclohexyl]ammonium trifluoroacetate; 2,4-Dichloro-5-nitropyrimidine; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 20 ℃;

With iron; acetic acid; at 20 ℃; for 2h;

Reference yield:

: 1467-84-1
((1R,4R)-4-aminocyclohexyl)methanol

: 1414805-52-9
{2-(1r,4r)-4-[(5-amino-2-chloropyrimidin-4-yl)amino]cyclohexyl}acetonitrile

Guidance literature:: Multi-step reaction with 6 steps

1: tetrahydrofuran / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: dimethyl sulfoxide / 20 h / 55 °C

4: hydrogenchloride / 1,4-dioxane / 20 °C

5: N-ethyl-N,N-diisopropylamine / dichloromethane / -78 - 20 °C / Inert atmosphere

6: tin(II) chloride dihdyrate / ethanol / 3 h / 80 °C / Sealed tube

With hydrogenchloride; tin(II) chloride dihdyrate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/acs.jmedchem.9b00533