C₁₃H₁₈N₂O₂*ClH

Base Information

• Chemical Name: C₁₃H₁₈N₂O₂*ClH
• CAS No.: 1352619-33-0
• Molecular Formula: C₁₃H₁₈N₂O₂*ClH
• Molecular Weight: 270.759
• Mol file: 1352619-33-0.mol

Synonyms:C₁₃H₁₈N₂O₂*ClH

Chemical Property of C₁₃H₁₈N₂O₂*ClH

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₃H₁₈N₂O₂*ClH

There total 3 articles about C₁₃H₁₈N₂O₂*ClH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime (874993-78-9) → C13H18N2O2*ClH (1352619-33-0)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 ℃; for 0.0833333h;

DOI:10.1021/ol203046n

Reference yield:

acetophenone (98-86-2) → C13H18N2O2*ClH (1352619-33-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: methanol; water / 18 h / Reflux

2.1: silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate / tetrahydrofuran / 0.08 h / 40 °C / Inert atmosphere

2.2: 1 h / 40 °C / Inert atmosphere

3.1: hydrogenchloride / diethyl ether / 0.08 h / 0 °C

With hydrogenchloride; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In tetrahydrofuran; methanol; diethyl ether; water;

DOI:10.1021/ol203046n

Reference yield:

O-methyl acetophenone oxime (3376-33-8) → C13H18N2O2*ClH (1352619-33-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate / tetrahydrofuran / 0.08 h / 40 °C / Inert atmosphere

1.2: 1 h / 40 °C / Inert atmosphere

2.1: hydrogenchloride / diethyl ether / 0.08 h / 0 °C

With hydrogenchloride; silver hexafluoroantimonate; dichloro(pentamethylcyclopentadienyl)rhodium (III) dimer; cesium acetate; In tetrahydrofuran; diethyl ether;

DOI:10.1021/ol203046n

upstream raw materials:

1-(2-morpholin-4-ylphenyl)ethanone O-methyloxime

O-methyl acetophenone oxime

acetophenone