1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Base Information

Chemical Name:1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine
CAS No.:1293295-02-9
Molecular Formula:C₂₂H₂₃FN₄O
Molecular Weight:378.449
Hs Code.:

Synonyms:1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Suppliers and Price of 1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

There total 3 articles about 1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 3612-20-2
1-phenylmethyl-4-piperidone

: 1293294-65-1
2-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]methylsulfonyl}benzo[d]-thiazole

: 1293295-02-9
1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; Inert atmosphere;
DOI:10.1039/c0cc05083k

Reference yield:

: 2101-87-3
p-methoxy-phenylazide

: 1293295-02-9
1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C / Inert atmosphere

With silver tetrafluoroborate; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; 1: Huisgen ligation reaction / 2: Julia Olefin synthesis;
DOI:10.1039/c0cc05083k

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1293295-02-9
1-benzyl-4-{fluoro[1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl]-methylene}piperidine

Guidance literature:: Multi-step reaction with 3 steps

1: copper(ll) sulfate pentahydrate; sodium azide / methanol / 5 h / 20 °C

2: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / 0 °C / Inert atmosphere

With silver tetrafluoroborate; sodium azide; copper(ll) sulfate pentahydrate; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; 2: Huisgen ligation reaction / 3: Julia Olefin synthesis;
DOI:10.1039/c0cc05083k