Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate

Base Information

• Chemical Name: Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate
• CAS No.: 866640-61-1
• Molecular Formula: C₃₁H₃₉N₃O₅
• Molecular Weight: 533.668
• Mol file: 866640-61-1.mol

Synonyms:Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate

Chemical Property of Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate

There total 3 articles about Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine (866718-44-7) + Cyclopropylamine (765-30-0) → Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate (866640-61-1)

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;

DOI:10.1248/cpb.c15-00221

Reference yield:

2-[2,6-dimethyl-4-({[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)phenoxy]-2-methylpropanoate (866640-93-9) → Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate (866640-61-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium tris(acetoxy)borohydride / methanol / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 20 °C

With sodium tris(acetoxy)borohydride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.c15-00221

Reference yield:

→ Ethyl 2-[4-[[cyclopropylcarbamoylmethyl-(5-methyl-2-phenyloxazol-4-ylmethyl)amino]methyl]-2,6-dimethylphenoxy]-2-methylpropanoate (866640-61-1)

Guidance literature:

upstream raw materials:

2-[2,6-dimethyl-4-({[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)phenoxy]-2-methylpropanoate

2N-{4-[(1-ethoxy-2-methyl-1-oxopropan-2-yl)oxy]-3,5-dimethylbenzyl}-N-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)-methyl]glycine

Cyclopropylamine

Downstream raw materials:

2-[4-({[2-(cyclopropylamino)-2-oxoethyl][(5-methyl-2-phenyl-1,3-oxazol-4-yl)methyl]amino}methyl)-2,6-dimethylphenoxy]-2-methylpropanoic acid