Technology Process of 7-Benzyl-3-phenyl-2,17-dioxa-6,9-diaza-tricyclo[10.2.2.15,8]heptadeca-1(15),5,7,12(16),13-pentaene-9-carboxylic acid tert-butyl ester
There total 13 articles about 7-Benzyl-3-phenyl-2,17-dioxa-6,9-diaza-tricyclo[10.2.2.15,8]heptadeca-1(15),5,7,12(16),13-pentaene-9-carboxylic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran;
Ambient temperature;
DOI:10.1021/ja00175a039
- Guidance literature:
-
Multi-step reaction with 10 steps
1: 97 percent / conc. H2SO4 / Heating
2: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT
3: 98 percent / H2, / 10percent Pd/C / ethyl acetate / 3 h
4: 99.8 percent / trifluoroacetic acid / CH2Cl2 / 3 h / 0 °C
5: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl3, 0 deg C, 15 min, 2.) 0 deg C to RT
6: 84 percent / trifluoroacetic acid / CH2Cl2 / 5 h / 0 °C
7: 87 percent / N-methylmorpholine / CH2Cl2 / 4 h / 0 °C
8: LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
9: pyridine / CH2Cl2 / 4 h / 0 °C
10: 84 percent / NaH / tetrahydrofuran / Ambient temperature
With
4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; sulfuric acid; hydrogen; potassium hydride; sodium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 1.) KH, 2.) 18-crown-6 / 1.) THF, RT, 20 min, 2.) RT
2: 98 percent / H2, / 10percent Pd/C / ethyl acetate / 3 h
3: 99.8 percent / trifluoroacetic acid / CH2Cl2 / 3 h / 0 °C
4: 1.) 1,3-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole hydrate / 1.) CHCl3, 0 deg C, 15 min, 2.) 0 deg C to RT
5: 84 percent / trifluoroacetic acid / CH2Cl2 / 5 h / 0 °C
6: 87 percent / N-methylmorpholine / CH2Cl2 / 4 h / 0 °C
7: LiAlH4 / tetrahydrofuran / 0.25 h / 0 °C
8: pyridine / CH2Cl2 / 4 h / 0 °C
9: 84 percent / NaH / tetrahydrofuran / Ambient temperature
With
4-methyl-morpholine; pyridine; lithium aluminium tetrahydride; 18-crown-6 ether; hydrogen; potassium hydride; sodium hydride; 1-hydroxybenzotriazol-hydrate; dicyclohexyl-carbodiimide; trifluoroacetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; dichloromethane; ethyl acetate;
DOI:10.1021/ja00175a039
![4-Nitro-benzenesulfonic acid 2-{4-[2-(4-benzyl-5-tert-butoxycarbonylamino-oxazol-2-yl)-1-phenyl-ethoxy]-phenyl}-ethyl ester](/Databaselist/images/loading.webp)
