C₂₇H₅₁BO₄Si

Base Information

• Chemical Name: C₂₇H₅₁BO₄Si
• CAS No.: 303964-24-1
• Molecular Formula: C₂₇H₅₁BO₄Si
• Molecular Weight: 478.596
• Mol file: 303964-24-1.mol

Synonyms:C₂₇H₅₁BO₄Si

Chemical Property of C₂₇H₅₁BO₄Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₇H₅₁BO₄Si

There total 10 articles about C₂₇H₅₁BO₄Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-benzyloxy-2-methylpentan-3-one (116546-78-2) → C27H51BO4Si (303964-24-1)

Guidance literature:

Multi-step reaction with 10 steps

1.1: Et₃N / diethyl ether / 2 h / 0 °C

2.1: diethyl ether / 23 h / -78 - -20 °C

3.1: lithium borohydride / diethyl ether; tetrahydrofuran / 3 h / -78 °C

3.2: 30percent aq. H₂O₂; 10percent aq. NaOH / methanol / 0 - 20 °C

4.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -78 °C

5.1: 69 percent / CSA / methanol; CH₂Cl₂ / 8 h / 0 °C

6.1: 100 percent / H₂ / Pd(OH)2/C / ethanol / 16 h / 20 °C

7.1: oxalyl chloride; dimethyl sulfoxide / CH₂Cl₂ / 2 h / -78 - -50 °C

8.1: sodium chlorite; sodium dihydrogen orthophosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

9.1: diethyl ether / 20 °C

10.1: Et₃N / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; 2-methyl-but-2-ene; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; tert-butyl alcohol; 7.1: Swern oxidation;

DOI:10.1021/ja011211m

Reference yield:

(2S,3R,4S,5S)-1-benzyloxy-2,4-dimethylhexane-3,5-diol (261968-09-6) → C27H51BO4Si (303964-24-1)

Guidance literature:

Multi-step reaction with 7 steps

1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -78 °C

2: 69 percent / CSA / methanol; CH₂Cl₂ / 8 h / 0 °C

3: 100 percent / H₂ / Pd(OH)2/C / ethanol / 16 h / 20 °C

4: oxalyl chloride; dimethyl sulfoxide / CH₂Cl₂ / 2 h / -78 - -50 °C

5: sodium chlorite; sodium dihydrogen orthophosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

6: diethyl ether / 20 °C

7: Et₃N / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; 2-methyl-but-2-ene; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In methanol; diethyl ether; ethanol; dichloromethane; water; tert-butyl alcohol; 4: Swern oxidation;

DOI:10.1021/ja011211m

Reference yield:

C25H39BO2 (152192-50-2) → C27H51BO4Si (303964-24-1)

Guidance literature:

Multi-step reaction with 9 steps

1.1: diethyl ether / 23 h / -78 - -20 °C

2.1: lithium borohydride / diethyl ether; tetrahydrofuran / 3 h / -78 °C

2.2: 30percent aq. H₂O₂; 10percent aq. NaOH / methanol / 0 - 20 °C

3.1: 99 percent / 2,6-lutidine / CH₂Cl₂ / 2 h / -78 °C

4.1: 69 percent / CSA / methanol; CH₂Cl₂ / 8 h / 0 °C

5.1: 100 percent / H₂ / Pd(OH)2/C / ethanol / 16 h / 20 °C

6.1: oxalyl chloride; dimethyl sulfoxide / CH₂Cl₂ / 2 h / -78 - -50 °C

7.1: sodium chlorite; sodium dihydrogen orthophosphate; 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 2 h / 20 °C

8.1: diethyl ether / 20 °C

9.1: Et₃N / diethyl ether / 1 h / 0 °C

With 2,6-dimethylpyridine; sodium chlorite; sodium dihydrogenphosphate; lithium borohydride; 2-methyl-but-2-ene; oxalyl dichloride; camphor-10-sulfonic acid; hydrogen; dimethyl sulfoxide; triethylamine; palladium dihydroxide; In tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; water; tert-butyl alcohol; 6.1: Swern oxidation;

DOI:10.1021/ja011211m

upstream raw materials:

dicyclohexylboron chloride

methyl (2R,3S,4R)-3-(t-butyldimethylsilyloxy)-2,4-dimethyl-5-oxohexanoate

(S)-1-benzyloxy-2-methylpentan-3-one

2(S)-methyl-3(R)-<(tert-butyldimethylsilyl)oxy>-4(S)-methyl-5-(S)-hydroxyhexan-1-ol