1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

Base Information

• Chemical Name: 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol
• CAS No.: 123796-65-6
• Molecular Formula: C₂₄H₂₉NO₅
• Molecular Weight: 411.498
• Mol file: 123796-65-6.mol

Synonyms:1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

Chemical Property of 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol

There total 13 articles about 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

Methyl 1-<2,6-Dimethoxy-4-((E)-2-nitropropenyl)phenyl>-4,5-dimethoxynaphthalene-2-carboxylate (134822-51-8) → 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2.5h; Heating;

DOI:10.1039/P19910000841

Reference yield: 82.0%

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester (123796-64-5) → 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 2.5h; Heating;

DOI:10.1039/c39890000301

Reference yield:

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate (123796-63-4) → 1-<4-(2-Aminopropyl)-2,6-dimethoxyphenyl>-4,5-dimethoxy-2-naphthylmethanol (123796-65-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / NH₄OAc / acetic acid / 1.5 h / 80 °C

2: 82 percent / LiAlH₄ / tetrahydrofuran / 2.5 h / Heating

With lithium aluminium tetrahydride; ammonium acetate; In tetrahydrofuran; acetic acid;

DOI:10.1039/c39890000301

upstream raw materials:

Methyl 1-<2,6-Dimethoxy-4-((E)-2-nitropropenyl)phenyl>-4,5-dimethoxynaphthalene-2-carboxylate

1-[2,6-Dimethoxy-4-((Z)-2-nitro-propenyl)-phenyl]-4,5-dimethoxy-naphthalene-2-carboxylic acid methyl ester

Methyl 1-(4-Formyl-2,6-dimethoxyphenyl)-4,5-dimethoxynaphthalene-2-carboxylate

4-bromo-3,5-dimethoxybenzaldehyde

Downstream raw materials:

ancistrocladisine

N-<2-<4-(4,5-Dimethoxy-2-methyl-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

N-<2-<2-(Hydroxymethyl-4,5-dimethoxy-1-naphthyl)-3,5-dimethoxyphenyl>-1-methylethyl>acetamide

Acetic acid 1-[4-(2-acetylamino-propyl)-2,6-dimethoxy-phenyl]-4,5-dimethoxy-naphthalen-2-ylmethyl ester