(R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide

Base Information

• Chemical Name: (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide
• CAS No.: 244092-54-4
• Molecular Formula: C₁₂H₁₇NO₂S
• Molecular Weight: 239.338
• Mol file: 244092-54-4.mol

Synonyms:(R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property of (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide

There total 2 articles about (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxy-benzaldehyde (123-11-5) + (R)-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tert-butanesulfinate (159263-57-7) → (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide (244092-54-4)

Guidance literature:

(R)-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tert-butanesulfinate; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃; for 0.25h; Inert atmosphere;

4-methoxy-benzaldehyde; With cesium fluoride; In tetrahydrofuran; at 0 ℃; Inert atmosphere;

DOI:10.1002/ejoc.201402673

Reference yield: 85.0%

4-methoxy-benzaldehyde (123-11-5) + (R)-2-methylpropane-2-sulfinamide (196929-78-9) → (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide (244092-54-4)

Guidance literature:

With copper(II) sulfate; In dichloromethane; at 20 ℃; for 18h;

DOI:10.1055/s-2003-42028

Reference yield: 96.0%

difluoromethyl phenyl sulfone (1535-65-5) + (R,E)-N-(4-methoxybenzylidene)-2-methylpropane-2-sulfinamide (244092-54-4) → (RS)-N-[(S)-2,2-difluoro-1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethyl]-2-methylpropane-2-sulfinamide

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.333333h;

DOI:10.1002/anie.200501769

upstream raw materials:

4-methoxy-benzaldehyde

(R)-2-methylpropane-2-sulfinamide

(R)-3-deoxy-1,2:5,6-di-O-isopropylidene-α-D-glucofuranos-3-yl tert-butanesulfinate

Downstream raw materials:

2-Methyl-propane-2-sulfinic acid [(1S,2R)-2-hydroxy-1-(4-methoxy-phenyl)-3-methyl-pentyl]-amide

2-Methyl-propane-2-sulfinic acid [(1S,2S)-3-benzyloxy-2-hydroxy-1-(4-methoxy-phenyl)-propyl]-amide

2-Methyl-propane-2-sulfinic acid [(1S,2R)-2-hydroxy-1-(4-methoxy-phenyl)-3-methyl-butyl]-amide