N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide
• CAS No.: 1131906-51-8
• Molecular Formula: C₂₃H₂₃NO₄S
• Molecular Weight: 409.506
• Mol file: 1131906-51-8.mol

Synonyms:N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide

There total 3 articles about N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

1,1-bis(4-methoxyphenyl)-2-methoxyethene (40264-36-6) → N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide (1131906-51-8)

Guidance literature:

1,1-bis(4-methoxyphenyl)-2-methoxyethene; With toluene-4-sulfonamide; In dichloromethane;

With bis(trifluoromethyl)dicarbonate; trifluoroacetic acid; In dichloromethane; at 20 ℃; Reflux;

DOI:10.1055/s-0028-1087413

Reference yield: 67.0%

4-toluenesulfonyl azide (941-55-9) + methoxybenzene (100-66-3) + 4-methoxyphenylacetylen (768-60-5) → N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide (1131906-51-8)

Guidance literature:

With bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]}; at 25 - 100 ℃; for 3.5h; regioselective reaction; Inert atmosphere;

DOI:10.1021/acs.joc.5b00891

Reference yield:

4-toluenesulfonyl azide (941-55-9) + 4-methoxyphenylacetylen (768-60-5) → N-(2,2-bis(4-methoxyphenyl)vinyl)-4-methylbenzenesulfonamide (1131906-51-8)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(I) thiophene-2-carboxylate / 3 h / 20 °C / Inert atmosphere

2: bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]} / 1 h / 100 °C / Inert atmosphere

With copper(I) thiophene-2-carboxylate; bis{rhodium[3,3'-(1,3-phenylene)bis(2,2-dimethylpropanoic acid)]};

DOI:10.1021/acs.joc.7b03068

upstream raw materials:

1,1-bis(4-methoxyphenyl)-2-methoxyethene

4-toluenesulfonyl azide

methoxybenzene

4-methoxyphenylacetylen

Downstream raw materials:

6-methoxy-3-(4-methoxyphenyl)-1-(4-methylphenylsulfonyl)indole

bis(p-methoxyphenyl)methanone