5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Base Information

Chemical Name:5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate
CAS No.:1190971-64-2
Molecular Formula:C₂₀H₂₄N₂O₅
Molecular Weight:372.421
Hs Code.:

Synonyms:5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

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Chemical Property of 5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

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Technology Process of 5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

There total 6 articles about 5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1190971-62-0
ethyl 4-phenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridine-3-carboxylate

: 1190971-64-2
5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 620-08-6,1232006-56-2
4-methoxypyridine

: 1190971-64-2
5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: trimethylsilyl trifluoromethanesulfonate / tetrahydrofuran / -78 - 20 °C

1.2: 1 h / -78 °C

2.1: L-Selectride / tetrahydrofuran / -78 - 20 °C

3.1: toluene-4-sulfonic acid / toluene / 5 h / Reflux

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: hydrogenchloride; water / 0 - 130 °C

6.1: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; trimethylsilyl trifluoromethanesulfonate; water; L-Selectride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;

Reference yield:

: 1190971-55-1
1-acetyl-2-phenyl-2,3-dihydropyridin-4(1H)-one

: 1190971-64-2
5-tert-butyl 3-ethyl 4-phenyl-6,7-dihydroisoxazolo[4,5-c]pyridine-3,5(4H)-dicarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: L-Selectride / tetrahydrofuran / -78 - 20 °C

2: toluene-4-sulfonic acid / toluene / 5 h / Reflux

3: triethylamine / dichloromethane / 0 - 20 °C

4: hydrogenchloride; water / 0 - 130 °C

5: triethylamine / dichloromethane / 2 h / 20 °C

With hydrogenchloride; water; L-Selectride; toluene-4-sulfonic acid; triethylamine; In tetrahydrofuran; dichloromethane; toluene;