(2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

Base Information

Chemical Name:(2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone
CAS No.:80868-73-1
Molecular Formula:C₂₂H₃₂O₃Si
Molecular Weight:372.58
Hs Code.:

Synonyms:(2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

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Chemical Property of (2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

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Technology Process of (2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone

There total 20 articles about (2S,3S)-2-[3-(4-Methoxy-2-methyl-phenyl)-3-oxo-2-trimethylsilanyl-propyl]-2-methyl-3-vinyl-cyclopentanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 52289-54-0
4-methoxysalicylaldehyde

: 80868-73-1
rac-3-Methoxy-11ξ-trimethylsilyl-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-9,17-dion

Guidance literature:: Multi-step reaction with 3 steps

1: 1) Mg / 1) THF, 30 min. at 50 deg C; 2) ether, 12 h at room temp.

2: 80.4 percent / Jones-reagent / diethyl ether; H₂O / 15 h / Ambient temperature

3: 1) t-C₄H₉OH/Na; 2) 10 percent H₂SO₄ / 1) ether, 12 h, room temp.

With Jones-reagent; sulfuric acid; sodium; magnesium; tert-butyl alcohol; In diethyl ether; water;
DOI:10.1002/jlac.198119811220

Reference yield:

: 27060-75-9
4-bromo-3-methylanisole

: 80868-73-1
rac-3-Methoxy-11ξ-trimethylsilyl-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-9,17-dion

Guidance literature:: Multi-step reaction with 4 steps

1: 1) Mg / 1) THF, 1 h at 50 deg C; 2) THF, -40 deg C to -20 deg C in 2 h

2: 1) Mg / 1) THF, 30 min. at 50 deg C; 2) ether, 12 h at room temp.

3: 80.4 percent / Jones-reagent / diethyl ether; H₂O / 15 h / Ambient temperature

4: 1) t-C₄H₉OH/Na; 2) 10 percent H₂SO₄ / 1) ether, 12 h, room temp.

With Jones-reagent; sulfuric acid; sodium; magnesium; tert-butyl alcohol; In diethyl ether; water;
DOI:10.1002/jlac.198119811220

Reference yield:

: 57069-78-0
<(1SR,2Ξ)-2-Methyl-3-oxocyclopentyl>essigsaeure-methylester

: 80868-73-1
rac-3-Methoxy-11ξ-trimethylsilyl-6,7:8,9-diseco-1,3,5(10),7-oestratetraen-9,17-dion

Guidance literature:: Multi-step reaction with 5 steps

1: 88 percent / p-toluene sulfonic acid / toluene / 4 h / Heating

2: 95 percent / 1) LiAlH₄ / diethyl ether / 4 h / Heating

3: 61 percent / o-nitrophenylselenocyanate; tri-n-butylphosphane / tetrahydrofuran / 0.5 h / Ambient temperature

4: 84 percent / 15 percent HCl / diethyl ether / 1.5 h

5: 1) t-C₄H₉OH/Na; 2) 10 percent H₂SO₄ / 1) ether, 12 h, room temp.

With hydrogenchloride; lithium aluminium tetrahydride; ortho-nitrophenyl selenocyanate; tributylphosphine; sulfuric acid; sodium; toluene-4-sulfonic acid; tert-butyl alcohol; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1002/jlac.198119811220