6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one

Base Information

• Chemical Name: 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one
• CAS No.: 473927-67-2
• Molecular Formula: C₂₀H₁₈IN₃O₄S
• Molecular Weight: 523.351

Synonyms:6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one

Chemical Property of 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one

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Technology Process of 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one

There total 1 articles about 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one (473927-69-4) + (Z)-N'-(4-methoxyphenyl)-1-(methylsulfonyl)methanehydrazonoyl chloride (473927-66-1) → 6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one (473927-67-2)

Guidance literature:

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one; (Z)-N'-(4-methoxyphenyl)-1-(methylsulfonyl)methanehydrazonoyl chloride; With triethylamine; In toluene; at 70 ℃; for 12h;

With hydrogenchloride; at 20 ℃; for 4h; Further stages.;

DOI:10.1021/jm070245n

Reference yield: 80.0%

6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one (473927-67-2) + 2-formylbenzene boronic acid (40138-16-7) → 4'-[3-methanesulfonyl-1-(4-methoxyphenyl)-7-oxo-1,4,5,6-tetrahydropyrazolo[3,4-c]pyridin-6-yl]biphenyl-2-carbaldehyde

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; for 24h; Heating;

DOI:10.1021/jm070245n

Reference yield:

6-(4-iodophenyl)-1-(4-methoxyphenyl)-3-(methylsulfonyl)-1,4,5,6-tetrahydro-7H-pyrazolo(3,4-c)pyridin-7-one (473927-67-2) + 4-benzyloxycarbonylpiperazin-2-one (78818-15-2) → C32H31N5O7S

Guidance literature:

With copper(l) iodide; potassium carbonate; In dimethyl sulfoxide; at 130 ℃; for 18h; Inert atmosphere;

upstream raw materials:

1-(4-iodo-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one

(Z)-N'-(4-methoxyphenyl)-1-(methylsulfonyl)methanehydrazonoyl chloride

Downstream raw materials:

1-(4-methoxyphenyl)-3-(methylsulfonyl)-6-[4-(2-oxo-1-piperazinyl)phenyl]-1,4,5,6-tetrahydro-7H-pyrazolo[3,4-c]pyridin-7-one

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