6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

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Chemical Name:6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate
CAS No.:1240299-36-8
Molecular Formula:C₄H₄O₄*C₂₅H₃₂F₃N₇O₂
Molecular Weight:635.643
Hs Code.:

Synonyms:6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

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Chemical Property of 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

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Technology Process of 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

There total 12 articles about 6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1240299-33-5
1-(4-(2-(4-(1-(3-(trifluoromethyl)-7,8-dihydro-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)piperidin-4-yl)phenoxy)ethyl)piperazin-1-yl)ethanone

: 110-16-7,26099-09-2
maleic acid

: 1240299-36-8
6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

Guidance literature:: In methanol; at 22 - 50 ℃;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1240299-36-8
6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 0 - 25 °C / Inert atmosphere

4.1: hydrogen / 5%-palladium/activated carbon / isopropyl alcohol / 2 h / 40 °C / 3750.38 Torr

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

6.1: hydrogen / palladium 10% on activated carbon / methanol / 10 h / 50 °C / 3750.38 Torr / Autoclave

7.1: methanol / 22 - 50 °C

With di-isopropyl azodicarboxylate; hydrogen; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; palladium 10% on activated carbon; In tetrahydrofuran; 1,4-dioxane; methanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 1240300-02-0
tert-butyl 4-[2-[4-(piperidin-4-yl)phenoxy]ethyl]piperazine-1-carboxylate

: 1240299-36-8
6-(4-{4-[2-(4-acetylpiperazin-1-yl)ethoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine maleate

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 2 h / 80 °C

2.1: ammonium formate / palladium 10% on activated carbon / ethanol / 78 °C

3.1: trifluoroacetic acid / dichloromethane / 1 h / 18 - 25 °C

3.2: 18 - 25 °C

4.1: triethylamine / dichloromethane / 0 - 25 °C / Inert atmosphere

5.1: methanol / 22 - 50 °C

With ammonium formate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;