Technology Process of 5,6-bis-benzyloxy-2-(2,6-bis-benzyloxy-4-methoxy-phenyl)-benzofuran-3-carboxylic acid methyl ester
There total 10 articles about 5,6-bis-benzyloxy-2-(2,6-bis-benzyloxy-4-methoxy-phenyl)-benzofuran-3-carboxylic acid methyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
carbon tetrabromide; caesium carbonate; thiourea;
palladium(II) iodide;
In
tetrahydrofuran;
at 50 ℃;
for 2h;
DOI:10.1021/jo030228f
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: m-chloroperbenzoic acid / CH2Cl2; H2O / 15 h / 20 °C
1.2: 90 percent / K2CO3 / methanol / 0.5 h / 25 °C
2.1: 99 percent / Et3N / tetrahydrofuran / 2 h / 25 °C
3.1: 94 percent / N-iodosuccinimide; trifluoroacetic acid / acetonitrile / 12 h / 40 °C
4.1: 90 percent / CuI; Et3N / PdCl2(PPh3)2 / acetonitrile / 12 h / 25 °C
5.1: 98 percent / hydrazine monohydrate / tetrahydrofuran / 2 h / 25 °C
6.1: 87 percent / thiourea; Cs2CO3; CBr4 / PdI2 / tetrahydrofuran / 2 h / 50 °C
With
N-iodo-succinimide; copper(l) iodide; carbon tetrabromide; caesium carbonate; hydrazine hydrate; triethylamine; thiourea; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; palladium(II) iodide;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
1.1: Baeyer-Villiger oxidation / 4.1: Sonogashira coupling reaction;
DOI:10.1021/jo030228f
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 99 percent / Et3N / tetrahydrofuran / 2 h / 25 °C
2: 94 percent / N-iodosuccinimide; trifluoroacetic acid / acetonitrile / 12 h / 40 °C
3: 90 percent / CuI; Et3N / PdCl2(PPh3)2 / acetonitrile / 12 h / 25 °C
4: 98 percent / hydrazine monohydrate / tetrahydrofuran / 2 h / 25 °C
5: 87 percent / thiourea; Cs2CO3; CBr4 / PdI2 / tetrahydrofuran / 2 h / 50 °C
With
N-iodo-succinimide; copper(l) iodide; carbon tetrabromide; caesium carbonate; hydrazine hydrate; triethylamine; thiourea; trifluoroacetic acid;
bis-triphenylphosphine-palladium(II) chloride; palladium(II) iodide;
In
tetrahydrofuran; acetonitrile;
3: Sonogashira coupling reaction;
DOI:10.1021/jo030228f
