3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

Base Information

Chemical Name:3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether
CAS No.:1801862-02-1
Molecular Formula:C₁₄H₇Cl₂F₂N₃O₂
Molecular Weight:358.131
Hs Code.:

Synonyms:3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

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Chemical Property of 3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

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Technology Process of 3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

There total 3 articles about 3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.2%

: 3-chloro-2-[3-(difluoromethyl)-5-isoxazolyl]-phenol

: 38275-47-7
5-chloro-2-(methylsulfonyl)pyrimidine

: 1801862-02-1
3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

Guidance literature:: With potassium carbonate; In isopropyl alcohol; at 65 ℃; for 1h; Inert atmosphere;

Reference yield:

: 2040-05-3
2,6 dichloroacetophenone

: 1801862-02-1
3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / N,N-dimethyl acetamide / 1 h / 25 - 35 °C / Inert atmosphere

1.2: 2.5 h / 150 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2.2: 1 h / 20 °C

3.1: potassium carbonate / isopropyl alcohol / 1 h / 65 °C / Inert atmosphere

With hydroxylamine hydrochloride; sodium methylate; sodium acetate; potassium carbonate; In methanol; N,N-dimethyl acetamide; isopropyl alcohol;

Reference yield:

: 4209-25-0
2-chloro-1-(2-chlorophenyl)ethanone

: 1801862-02-1
3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium methylate / N,N-dimethyl acetamide / 3.5 h / 25 - 150 °C

2.1: hydroxylamine hydrochloride; sodium acetate / methanol / 20 °C

2.2: 1 h

3.1: potassium carbonate / isopropyl alcohol / 1 h / 65 °C

With hydroxylamine hydrochloride; sodium methylate; sodium acetate; potassium carbonate; In methanol; N,N-dimethyl acetamide; isopropyl alcohol;