ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate

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Chemical Name:ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate
CAS No.:1259366-75-0
Molecular Formula:C₁₄H₁₉ClFN₃O₃
Molecular Weight:331.775
Hs Code.:

Synonyms:ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate

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Technology Process of ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate

There total 4 articles about ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1259278-72-2
(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone

: 105-36-2
ethyl bromoacetate

: 1259366-75-0
ethyl 2-((1S,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxycyclohexyl)ethanoate

: Ethyl 2-((1R,3S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)-1-hydroxy-cyclohexyl)ethanoate

Guidance literature:: ethyl bromoacetate; With chloro-trimethyl-silane; zinc; In tetrahydrofuran; at 20 ℃; for 0.25h; Inert atmosphere; Reflux;

(S)-3-(2-chloro-5-fluoropyrimidin-4-ylamino)cyclohexanone; In tetrahydrofuran; for 2h; Inert atmosphere;