(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

Base Information

Chemical Name:(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol
CAS No.:218766-10-0
Molecular Formula:C₂₈H₃₅NO₂Si
Molecular Weight:445.677
Hs Code.:

Synonyms:(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

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Chemical Property of (1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

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Technology Process of (1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

There total 3 articles about (1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 218766-10-0
(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 1.) i-Bu₂AlH*i-Bu₃Al / 1.) CH₂Cl₂, hexanes, -78 deg C, 150 min, 2.) CH₂Cl₂, hexanes, Et₂O, -78 deg C, overnight

With 1H-imidazole; i-Bu₂AlH*i-Bu₃Al; In N,N-dimethyl-formamide;
DOI:10.1021/jo980951j

Reference yield:

: 218766-08-6
(R)-2-(Benzhydrylidene-amino)-3-hydroxy-propionic acid methyl ester

: 218766-10-0
(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 86 percent / imidazole / dimethylformamide / 24 h / Ambient temperature

2: 1.) i-Bu₂AlH*i-Bu₃Al / 1.) CH₂Cl₂, hexanes, -78 deg C, 150 min, 2.) CH₂Cl₂, hexanes, Et₂O, -78 deg C, overnight

With 1H-imidazole; i-Bu₂AlH*i-Bu₃Al; In N,N-dimethyl-formamide;
DOI:10.1021/jo980951j

Reference yield:

: 100-58-3
phenylmagnesium bromide

: 208253-69-4
(R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

: 218766-10-0
(1R,2R)-2-(Benzhydrylidene-amino)-3-(tert-butyl-dimethyl-silanyloxy)-1-phenyl-propan-1-ol

Guidance literature:: With i-Bu₂AlH*i-Bu₃Al; Yield given. Multistep reaction; 1.) CH₂Cl₂, hexanes, -78 deg C, 150 min, 2.) CH₂Cl₂, hexanes, Et₂O, -78 deg C, overnight;
DOI:10.1021/jo980951j