5-(Hydroxyphenylmethyl)-1-methylimidazol

Base Information

• Chemical Name: 5-(Hydroxyphenylmethyl)-1-methylimidazol
• CAS No.: 24132-86-3
• Molecular Formula: C₁₁H₁₂N₂O
• Molecular Weight: 188.229
• Mol file: 24132-86-3.mol

Synonyms:5-(Hydroxyphenylmethyl)-1-methylimidazol

Chemical Property of 5-(Hydroxyphenylmethyl)-1-methylimidazol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(Hydroxyphenylmethyl)-1-methylimidazol

There total 4 articles about 5-(Hydroxyphenylmethyl)-1-methylimidazol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

5-(1-hydroxy-1-phenylmethyl)-1-methyl-2-phenylthio-1H-imidazole → 5-(Hydroxyphenylmethyl)-1-methylimidazol (24132-86-3)

Guidance literature:

With Raney Ni W-2; In ethanol; for 4h; Heating;

DOI:10.1248/cpb.40.2681

Reference yield:

phenylmagnesium bromide (100-58-3) + 1-methyl-2-triethylsilylimidazole-5-carboxaldehyde (371765-89-8) → 5-(Hydroxyphenylmethyl)-1-methylimidazol (24132-86-3)

Guidance literature:

In tetrahydrofuran; methanol; water; ethyl acetate;

Reference yield:

benzaldehyde (100-52-7) + 1-Methyl-5-(trimethylsilyl)imidazol (50694-57-0) → 5-(Hydroxyphenylmethyl)-1-methylimidazol (24132-86-3)

Guidance literature:

With water; cesium fluoride; Yield given. Multistep reaction; 1) DMF, 120 min, 90 deg C, 2) 90 deg C, 5 min;

upstream raw materials:

benzaldehyde

1-Methyl-5-(trimethylsilyl)imidazol

phenylmagnesium bromide

1-methyl-2-triethylsilylimidazole-5-carboxaldehyde