5-[(TRIMETHYLSILYL)]-1-METHYLIMIDAZOLE

Base Information

• Chemical Name: 5-[(TRIMETHYLSILYL)]-1-METHYLIMIDAZOLE
• CAS No.: 50694-57-0
• Molecular Formula: C7H14N2Si
• Molecular Weight: 154.29
• Mol file: 50694-57-0.mol

Synonyms:1-methyl-5-trimethylsilyl-imidazole;1-Methyl-5-trifluormethyl-tetrazol;1-methyl-5-trifluoromethyltetrazole;1-methyl-5-trifluoromethyl-1H-tetrazole;1-methyl-5-trimethylsilanyl-1H-imidazole;

Chemical Property of 5-[(TRIMETHYLSILYL)]-1-METHYLIMIDAZOLE

Chemical Property:

• PSA: 17.82000
• LogP: 0.96530

Purity/Quality:

98% ^*data from raw suppliers

1-methyl-5-(trimethylsilyl)-1H-Imidazole 97.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-[(TRIMETHYLSILYL)]-1-METHYLIMIDAZOLE

There total 4 articles about 5-[(TRIMETHYLSILYL)]-1-METHYLIMIDAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methyl-2,5-bis(trimethylsilyl)imidazole (50694-52-5) → 1-Methyl-5-(trimethylsilyl)imidazol (50694-57-0)

Guidance literature:

With methanol; for 1h; Ambient temperature;

Reference yield: 81.0%

N-methyl-5-chloroimidazole (872-49-1) + chloro-trimethyl-silane (75-77-4) → 1-Methyl-5-(trimethylsilyl)imidazol (50694-57-0)

Guidance literature:

With magnesium; In tetrahydrofuran; for 3h; Heating;

Reference yield:

chloro-trimethyl-silane (75-77-4) + 2,5-dibromo-1-methyl-1H-imidazole (53857-59-3) → 1-Methyl-5-(trimethylsilyl)imidazol (50694-57-0)

Guidance literature:

With n-butyllithium; Yield given. Multistep reaction; 1.) THF, LiBr, -70 deg C, 2.) -70 deg C;

DOI:10.1016/S0040-4039(00)79166-0

upstream raw materials:

N-methyl-5-chloroimidazole

chloro-trimethyl-silane

2,5-dibromo-1-methyl-1H-imidazole

1-methyl-2,5-bis(trimethylsilyl)imidazole

Downstream raw materials:

5-(Hydroxyphenylmethyl)-1-methylimidazol

2-Benzoyl-1-methyl-5-(trimethylsilyl)imidazol

Refernces

• 1、 Effenberger, Franz,Roos, Michael,Ahmad, Roshan,Krebs, Andreas. "Carbodesilylation of (Trimethylsilyl)imidazoles and -pyrazoles". . p. 1639 - 1650. Retrieved 2007/10/02.
• 2、 Carpenter, Andrew J.,Chadwick, Derek J.,Ngochindo Raphael I.. "STUDIES ON THE DILITHIATION OF 1-METHYLIMIDAZOLE. OPTIMISATION OF REACTION CONDITIONS FOR SYNTHESES OF 2,5-DISUBSTITUTED DERIVATIVES". . p. 1913 - 1941. Retrieved 2007/10/02.