(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

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Chemical Name:(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one
CAS No.:544711-71-9
Molecular Formula:C₃₁H₄₅NO₆S
Molecular Weight:559.767
Hs Code.:

Synonyms:(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

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Chemical Property of (4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

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Technology Process of (4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

There total 7 articles about (4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 98-59-9
p-toluenesulfonyl chloride

: 544711-65-1
(4R,5R)-5-(2,3-dihydroxypropyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 544711-71-9
(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: (4R,5R)-5-(2,3-dihydroxypropyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one; With (C₄H₉)2SnO; In methanol;

p-toluenesulfonyl chloride; With triethylamine; In methanol;
DOI:10.1021/ol034369f

Reference yield:

: 102225-88-7
(-)-(S)-1-(2,4,6-triisopropylphenyl)ethanol

: 544711-71-9
(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium hydride / tetrahydrofuran / 2 h

1.2: 79 percent / tetrahydrofuran / 2.5 h / -50 - 20 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

2.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

3.1: dibutyltin oxide / methanol / 3 h / Heating

3.2: 87 percent / triethylamine / methanol / 2 h / 0 - 20 °C

With n-butyllithium; potassium hydride; di(n-butyl)tin oxide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo050983o

Reference yield:

: 220416-57-9
2-((1S)-1-((1E)-1,2-dichloroethenyloxy)ethyl)-1,3,5-triisopropylbenzene

: 544711-71-9
(4R,5R)-5-(2-hydroxy-3-(toluene-4-sulfonyloxy)propyl)-4-[(S)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -90 - -40 °C

1.2: HMPA / tetrahydrofuran; hexane / -40 - 0 °C

2.1: dibutyltin oxide / methanol / 3 h / Heating

2.2: 87 percent / triethylamine / methanol / 2 h / 0 - 20 °C

With n-butyllithium; di(n-butyl)tin oxide; In tetrahydrofuran; methanol; hexane;
DOI:10.1021/jo050983o